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FDFT1 gene

Known as: SQUALENE SYNTHASE, FDFT1, farnesyl-diphosphate farnesyltransferase 1 
National Institutes of Health

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Related topics

2 relations
Farnesyl-diphosphate farnesyltransferase

Broader (1)

Genes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes Published, JLR Papers in Press, October 16, 2002. DOI 10.1194/jlr.M200316-JLR200
We recently demonstrated that squalene synthase (SQS) inhibitors reduce plasma triglyceride through an LDL receptor-independent… 
2003
2003
Total synthesis of the squalene synthase inhibitor zaragozic acid C by a carbonyl ylide cycloaddition strategy.
Highly Cited
2002
Highly Cited
2002
Recombinant squalene synthase. Synthesis of non-head-to-tail isoprenoids in the absence of NADPH.
Squalene synthase (SQase) catalyzes two consecutive reactions in sterol biosynthesis. The first is the condensation of two… 
2002
2002
Cloning and expression of squalene synthase cDNA from hot pepper (Capsicum annuum L.).
Highly Cited
2000
Highly Cited
2000
Effect of ER-27856, a novel squalene synthase inhibitor, on plasma cholesterol in rhesus monkeys: comparison with 3-hydroxy-3-methylglutaryl-coa reductase inhibitors.
Squalene synthase (SQS; EC 2.5.1.21) plays an important role in the cholesterol biosynthetic pathway. We discovered ER-28448, 5… 
2000
2000
Inhibitors of Sterol Biosynthesis and Amphotericin B Reduce the Viability of Pneumocystis carinii f. sp.carinii
ABSTRACT Pneumocystis carinii synthesizes sterols with a double bond at C-7 of the sterol nucleus and an alkyl group with one or… 
1998
1998
Truncation of human squalene synthase yields active, crystallizable protein.
Squalene synthase catalyzes the first committed step in cholesterol biosynthesis and thus is important as a potential target for… 
1996
1996
alpha-Phosphonosulfonic acids: potent and selective inhibitors of squalene synthase.
Highly Cited
1994
Highly Cited
1994
Effect of squalene synthase inhibition on the expression of hepatic cholesterol biosynthetic enzymes, LDL receptor, and cholesterol 7 alpha hydroxylase.
Squalene synthase catalyzes the committed step in the biosynthesis of sterols. Treating rats with zaragozic acid A, a potent… 
Highly Cited
1993
Highly Cited
1993
Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase.
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