FANCL gene

Known as: Fanconi Anemia, Complementation Group L Gene, Pog, FAAP43 
This gene is involved in the mediation of protein ubiquitination.
National Institutes of Health

Related topics

Related topics

7 relations
Cell Cycle ControlDNA RepairDNA stabilityFanconi Anemia
(More)

Narrower (1)

FANCL wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Structure of the Human FANCL RING-Ube2T Complex Reveals Determinants of Cognate E3-E2 Selection
The combination of an E2 ubiquitin-conjugating enzyme with an E3 ubiquitin-ligase is essential for ubiquitin modification of a… (More)
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Sex Reversal in Zebrafish fancl Mutants Is Caused by Tp53-Mediated Germ Cell Apoptosis
The molecular genetic mechanisms of sex determination are not known for most vertebrates, including zebrafish. We identified a… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2010
2010
The structure of FANCL, the catalytic subunit of the Fanconi Anemia core complex
The Fanconi anemia (FA) pathway is activated in response to DNA damage, leading to monoubiquitination of the substrates FANCI and… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 1
Is this relevant?
2009
2009
FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL.
FANCI is integral to the Fanconi anemia (FA) pathway of DNA damage repair. Upon the occurrence of DNA damage, FANCI becomes… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI.
A key step in the Fanconi anemia (FA) tumor suppressor pathway is the site-specific monoubiquitination of the FANCD2 protein… (More)
  • figure 2
  • figure 3
  • figure 4
  • figure 5
  • figure 6
Is this relevant?
2007
2007
A requirement of FancL and FancD2 monoubiquitination in DNA repair.
The rare hereditary disorder Fanconi anemia (FA) can be caused by mutations in components of the FA core complex (FancA/B/C/E/F/G… (More)
Is this relevant?
2006
2006
The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly.
Fanconi anemia (FA) is an autosomal recessive disorder characterized by aplastic anemia, cancer susceptibility, and cellular… (More)
Is this relevant?
Highly Cited
2005
Highly Cited
2005
The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia
Seven Fanconi anemia–associated proteins (FANCA, FANCB, FANCC, FANCE, FANCF, FANCG and FANCL) form a nuclear Fanconi anemia core… (More)
  • figure 1
  • table 1
Is this relevant?
Highly Cited
2004
Highly Cited
2004
FANCL replaces BRCA1 as the likely ubiquitin ligase responsible for FANCD2 monoubiquitination.
Monoubiquitination of FANCD2 is a key step in the DNA damage response pathway involving Fanconi anemia proteins and the breast… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
A novel ubiquitin ligase is deficient in Fanconi anemia
Fanconi anemia is a recessively inherited disease characterized by congenital defects, bone marrow failure and cancer… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 1
Is this relevant?