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FANCL gene

Known as: Fanconi Anemia, Complementation Group L Gene, Pog, FAAP43 
This gene is involved in the mediation of protein ubiquitination.
National Institutes of Health

Related topics

Related topics

7 relations
Cell Cycle ControlDNA RepairDNA stabilityFanconi Anemia
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FANCL wt Allele

Papers overview

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Highly Cited
2014
Highly Cited
2014
Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies
Summary Background The epilepsies are a clinically heterogeneous group of neurological disorders. Despite strong evidence for… Expand
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Highly Cited
2014
Highly Cited
2014
The Genetic and Biochemical Basis of FANCD2 Monoubiquitination
Summary Fanconi anaemia (FA) is a cancer predisposition syndrome characterized by cellular sensitivity to DNA interstrand… Expand
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Highly Cited
2012
Highly Cited
2012
DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI
FANCI and FANCD2 form a complex, and play essential roles in the repair of interstrand DNA crosslinks (ICLs) by the Fanconi… Expand
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Highly Cited
2010
Highly Cited
2010
Sex Reversal in Zebrafish fancl Mutants Is Caused by Tp53-Mediated Germ Cell Apoptosis
The molecular genetic mechanisms of sex determination are not known for most vertebrates, including zebrafish. We identified a… Expand
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Highly Cited
2008
Highly Cited
2008
Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI.
A key step in the Fanconi anemia (FA) tumor suppressor pathway is the site-specific monoubiquitination of the FANCD2 protein… Expand
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Highly Cited
2006
Highly Cited
2006
UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation.
The Fanconi anemia pathway is required for the efficient repair of damaged DNA. A key step in this pathway is the… Expand
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Highly Cited
2005
Highly Cited
2005
The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia
Seven Fanconi anemia–associated proteins (FANCA, FANCB, FANCC, FANCE, FANCF, FANCG and FANCL) form a nuclear Fanconi anemia core… Expand
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Highly Cited
2005
Highly Cited
2005
The Fanconi anemia core complex associates with chromatin during S phase.
Fanconi anemia (FA) is an autosomal recessive disease marked by bone marrow failure, birth defects, and cancer. The FA proteins… Expand
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Highly Cited
2004
Highly Cited
2004
FANCL Replaces BRCA1 as the Likely Ubiquitin Ligase Responsible for FANCD2 Monoubiquitination
Monoubiquitination of FANCD2 is a key step in the DNA damage response pathway involving Fanconi anemia proteins and the breast… Expand
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Highly Cited
2003
Highly Cited
2003
A novel ubiquitin ligase is deficient in Fanconi anemia
Fanconi anemia is a recessively inherited disease characterized by congenital defects, bone marrow failure and cancer… Expand
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