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F10 wt Allele

Known as: Coagulation Factor X wt Allele, FX, FXA 
The F10 wt Allele is located in the vicinity of 13q34 and is approximately 27 kb in length. This allele, which encodes coagulation factor X protein… 
National Institutes of Health

Related topics

Related topics

9 relations
13q34Blood coagulationHomeostasisHomo sapiens

Broader (1)

F10 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Effect of BAX499 aptamer on tissue factor pathway inhibitor function and thrombin generation in models of hemophilia.
2006
2006
Antibodies against the Activated Coagulation Factor X (FXa) in the Antiphospholipid Syndrome That Interfere with the FXa Inactivation by Antithrombin1
Antiphospholipid Ab have been shown to promote thrombosis and fetal loss in the antiphospholipid syndrome (APS). Previously, we… 
Highly Cited
2005
Highly Cited
2005
Structural requirements for factor Xa inhibition by 3-oxybenzamides with neutral P1 substituents: combining X-ray crystallography, 3D-QSAR, and tailored scoring functions.
The design, synthesis, and structure-activity relationship of 3-oxybenzamides as potent inhibitors of the coagulation protease… 
Highly Cited
2002
Highly Cited
2002
Factor Xa Releases Matrix Metalloproteinase-2 (MMP-2) From Human Vascular Smooth Muscle Cells and Stimulates the Conversion of Pro–MMP-2 to MMP-2: Role of MMP-2 in Factor Xa–Induced DNA Synthesis and…
Pro–matrix metalloproteinase-2 (pro–MMP-2) is expressed in vascular smooth muscle cells (SMCs). We report that activated… 
Highly Cited
2002
Highly Cited
2002
Thrombin-mediated Proteolysis of Factor V Resulting in Gradual B-domain Release and Exposure of the Factor Xa-binding Site* 210
To investigate the relationship between the individual thrombin cleavages in factor V (FV) and the generation of activated factor… 
Highly Cited
2000
Highly Cited
2000
Binding of factor VIIa to tissue factor on human fibroblasts leads to activation of phospholipase C and enhanced PDGF-BB-stimulated chemotaxis.
Tissue factor (TF) is the cellular receptor for factor FVIIa (FVIIa), and the complex is the principal initiator of blood… 
Highly Cited
1998
Highly Cited
1998
Inhibition of Prothrombinase by Human Secretory Phospholipase A2 Involves Binding to Factor Xa*
Human group II secretory phospholipase A2 (hsPLA2) exhibits significant anticoagulant activity that does not require its… 
1998
1998
Tissue factor pathway inhibitor and anti-FXa kinetic profiles of a new low-molecular-mass heparin, Bemiparin, at therapeutic subcutaneous doses.
Low-molecular-mass heparins (LMMHs) exert an anti-FXa effect through antithrombin III (ATIII) and tissue factor pathway inhibitor… 
1996
1996
Role of Residue 99 at the S2 Subsite of Factor Xa and Activated Protein C in Enzyme Specificity*
It is thought that only a limited number of residues in the extended binding pocket of coagulation proteases are critical for… 
Highly Cited
1995
Highly Cited
1995
Antithrombotic effects of orally active synthetic antagonist of activated factor X in nonhuman primates.
BACKGROUND Since activated factor X (FXa) has a central role in hemostasis and thrombosis, it is an attractive target for… 
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