Experimental Organism Astrocytosis

Reactive astrogliosis is characterized by a profound change in astrocyte phenotype in response to all CNS injuries and diseases… (More)

Reactive astrocytosis develops in many neurologic diseases, including epilepsy. Astrocytotic contributions to pathophysiology are… (More)

Most strokes are covert and observed incidentally on brain scans, but their presence increases risk of overt stroke and dementia… (More)

Peptide amphiphile (PA) molecules that self-assemble in vivo into supramolecular nanofibers were used as a therapy in a mouse… (More)

Reactive astrocytosis occurs prominently in response to all forms of CNS injury or disease. The functions of reactive astrocytes… (More)

Glycogen synthase kinase-3beta (GSK-3beta) has been postulated to mediate Alzheimer's disease tau hyperphosphorylation, beta… (More)

Damage to the central nervous system (CNS) results in a glial reaction, leading eventually to the formation of a glial scar. In… (More)

Virtually any neurological disorder leads to activation of resident microglia and invasion of blood-borne macrophages, which are… (More)

Although atrophic changes have been well described following traumatic brain injury (TBI) in humans, little is known concerning… (More)

Cytokines are now recognized to play important roles in the physiology of the central nervous system (CNS) during health and… (More)