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Eukaryotic Initiation Factor-2, alpha Subunit

Known as: EIF 2alpha, EIF-2 alpha, Eukaryotic Initiation Factor 2, alpha Subunit 
National Institutes of Health

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Related topics

3 relations
EIF2S1 geneEIF2S1 wt Allele

Broader (1)

Eukaryotic Initiation Factor-2

Papers overview

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2013
2013
Abstract 1874: Phosphatidylcholine synthesis as a potential therapeutic target in multiple myeloma.
A metabolics screen with 8226 cells treated with AICAr showed that de novo pyrimidine synthesis was inhibited. AICAr -induced… 
2008
2008
2-Aminopurine Inhibits Lipid Accumulation Induced by Apolipoprotein E-Deficient Lipoprotein in Macrophages: Potential Role of Eukaryotic Initiation Factor-2α Phosphorylation in Foam Cell Formation
We previously reported that apolipoprotein (Apo) E-deficient, ApoB48-containing (E–/B48) lipoproteins inhibited expression of… 
2003
2003
Expression of translation initiation factor eIF-2alpha is increased in benign and malignant melanocytic and colonic epithelial neoplasms.
BACKGROUND Stimulation of resting cells by growth factors leads to an increase in the rate of protein synthesis, which is… 
2003
2003
C114 Is a Novel IL-11-inducible Nuclear Double-stranded RNA-binding Protein That Inhibits Protein Kinase R*
We have identified a cDNA (named C114) that encodes novel transcripts induced by IL-11 in mouse 3T3 L1 cells. Northern analysis… 
2002
2002
Lead exposure and heat shock inhibit cell proliferation in human HeLa and K562 cells by inducing expression and activity of the heme-regulated eIF-2alpha kinase.
We have used human cell lines, namely, K562 and HeLa cells as model systems in understanding the mechanism of lead toxicity and… 
2001
2001
Inhibition of protein synthesis in cortical neurons during exposure to hydrogen peroxide
Transient cerebral ischemia, which is accompanied by a sustained release of glutamate and zinc, as well as H2O2 formation during… 
2001
2001
AlaArg motif in the carboxyl terminus of the gamma(1)34.5 protein of herpes simplex virus type 1 is required for the formation of a high-molecular-weight complex that dephosphorylates eIF-2alpha.
The gamma(1)34.5 protein of herpes simplex virus (HSV) type 1 functions to prevent the shutoff of protein synthesis mediated by… 
1999
1999
Resistance of initiation factor 2 (eIF-2alpha) kinases to staurosporine: an approach for assaying the kinases in crude extracts.
1997
1997
Mutations at the Ser50 residue of translation factor eIF-2alpha dominantly affect developmental rate, body weight, and viability of Drosophila melanogaster.
Phosphorylation of the translation initiation factor eIF-2alpha downregulates protein synthesis by sequestering the guanylate… 
1996
1996
The outcome of poliovirus infections in K562 cells is cytolytic rather than persistent after hemin-induced differentiation
K562-Mu erythroleukemia cells readily establish a long-term persistent poliovirus infection characterized by continuous virus… 
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