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Eprotirome

A thyroid hormone analog with hypocholesterolemic properties. Eprotirome reduces serum LDL cholesterol levels by increasing hepatic clearance due to… Expand
National Institutes of Health

Papers overview

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2017
2017
&NA; The thyroid hormone (TH) analog eprotirome (KB2115) was developed to lower cholesterol through selective activation of the… Expand
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2017
2017
Although the hepatomitogenic activity of T3 is well established, the wide range of harmful effects exerted by this hormone… Expand
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2016
2016
Sobetirome binds selectively to the main hepatic form of thyroid hormone (TH) receptor, TRβ1, compared to TRα1, which is… Expand
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2015
2015
Liver‐selective thyromimetic agents could provide a new approach for treating dyslipidaemia. 
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Highly Cited
2014
Highly Cited
2014
BACKGROUND Eprotirome is a liver-selective thyroid hormone receptor agonist that has been shown to lower plasma LDL cholesterol… Expand
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2014
2014
Reduced plasma LDL-cholesterol is a hallmark of hyperthyroidism and is caused by transcriptional stimulation of LDL receptors in… Expand
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2012
2012
Thyromimetics that specifically target TRβ have been shown to reduce plasma cholesterol levels and avoid atherosclerosis through… Expand
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Review
2011
Review
2011
  • K. Parhofer
  • Current pharmaceutical design
  • 2011
  • Corpus ID: 25067837
Elevated levels of lipoprotein(a) are causally related to premature atherosclerosis. It is therefore of interested to evaluate by… Expand
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Dyslipidemia increases the risk of atherosclerotic cardiovascular disease and is incompletely reversed by statin… Expand
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2009
2009
Nonalcoholic fatty liver disease (NAFLD) is defined as the accumulation of fat in the liver in the absence of alcohol consumption… Expand
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