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Epitope Spreading

A normal feature of responses to infectious agents that allows recognition of multiple antigenic targets, Epitope Spreading involves non-cross… 
National Institutes of Health

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AntigensImmunity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Abstract A137: Multi-modal treatment with peptide vaccine, metronomic cyclophosphamide and PD-1 blockade provides effective tumor control through a mechanism of epitope spreading
Future cancer immunotherapies will combine multiple treatments to improve immune responses to cancer through synergistic, multi… 
2014
2014
Long‐term suppression of EAE relapses by pharmacological impairment of epitope spreading
Immune events sustaining dendritic cell (DC)‐dependent epitope spreading (ES) are of key relevance to the development of relapses… 
Review
2013
Review
2013
OP0084 Patterns of circulating antibodies in the pre-clinical phase of rheumatoid arthritis suggest epitope spreading in the immune reaction against citrullinated peptides
Background Previous studies indicate that anti-citrullinated peptide antibodies (ACPAs) may be detected in individuals who later… 
2012
2012
Abstract OT3-1-02: Phase II randomized study of combination immunotherapy with or without Polysaccharide Krestin (PSK®) concurrently with a HER2 ICD peptide-based vaccine and trastuzumab in patients…
Background: Endogenous immunity in patients with HER2+ metastatic breast cancer (MBC) is likely dampened by an immune-suppressive… 
2012
2012
Abstract P5-16-04: A phase I study of a DNA plasmid based vaccine encoding the HER-2/neu intracellular domain in subjects with HER2+ breast cancer.
HER2+ breast cancer (BC) is associated with early disease relapse, usually to distant sites. This would suggest relapse is due to… 
Review
2010
Review
2010
Peripherin-IgG association with neurologic and endocrine autoimmunity.
2009
2009
Study of HER-2/neu Intracellular Domain Peptide-Based Vaccine Administered to Stage IV HER2 Positive Breast Cancer Patients Receiving Trastuzumab. Phase 2
Abstract : The primary purpose of this grant is to determine the relapse free survival benefit with locally advanced and stage IV… 
2008
2008
Role of the transgenic human thyrotropin receptor A‐subunit in thyroiditis induced by A‐subunit immunization and regulatory T cell depletion
Transgenic BALB/c mice that express intrathyroidal human thyroid stimulating hormone receptor (TSHR) A‐subunit, unlike wild‐type… 
2003
2003
Epitope Spreading Is Not Required for Relapses in Experimental Autoimmune Encephalomyelitis1
The sequential emergence of specific T lymphocyte-mediated immune reactivity directed against multiple distinct myelin epitopes… 
2001
2001
Pre-Emptive Targeting of the Epitope Spreading Cascade with Genetically Modified Regulatory T Cells During Autoimmune Demyelinating Disease1
Epitope spreading or endogenous self-priming has been implicated in mediating the progression of autoimmune disease. In the… 
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