Endothelium-Dependent Relaxing Factors

Known as: Endothelium-Dependent Relaxing Factor, Endothelium Dependent Relaxing Factors, Endothelium Derived Relaxant Factor 
Paracrine substances produced by the VASCULAR ENDOTHELIUM with VASCULAR SMOOTH MUSCLE relaxation (VASODILATION) activities. Several factors have been… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1953-2018
020406019532017

Papers overview

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Review
2016
Review
2016
INTRODUCTION Dysfunction of vessel endothelium is the first step in a complex and multi-faceted process that eventually leads to… (More)
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Highly Cited
1998
Highly Cited
1998
In arteries, muscarinic agonists such as acetylcholine release an unidentified, endothelium-derived hyperpolarizing factor (EDHF… (More)
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Highly Cited
1994
Highly Cited
1994
NITRIC oxide is the major endothelium-derived relaxing factor (EDRF)1–3, and it is thought to relax smooth muscle cells by… (More)
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Highly Cited
1992
Highly Cited
1992
The endothelium plays a pivotal role in modulating the reactivity of vascular smooth muscle through the formation of several… (More)
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Highly Cited
1991
Highly Cited
1991
The characteristics of carbon monoxide (CO)-induced, endothelium-independent relaxation of rabbit aorta were compared with those… (More)
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Highly Cited
1990
Highly Cited
1990
ATHEROSCLEROSIS in animals and humans is associated with an unresponsiveness of arteries and arterioles to endothelium-dependent… (More)
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Highly Cited
1990
Highly Cited
1990
BACKGROUND Endothelium regulates vascular tone by influencing the contractile activity of vascular smooth muscle. This regulatory… (More)
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Highly Cited
1987
Highly Cited
1987
The objective of this study was to determine whether nitric oxide (NO) is responsible for the vascular smooth muscle relaxation… (More)
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Highly Cited
1986
Highly Cited
1986
To test the hypothesis that atherosclerosis impairs endothelium-dependent vascular relaxation, we examined the effect of the… (More)
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Highly Cited
1986
Highly Cited
1986
We studied the effects of hypercholesterolemia on vascular responsiveness in different arteries isolated from rabbits: control… (More)
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