Ecto-Phosphoprotein Phosphatase

As part of its pathogenesis, Legionella pneumophila persists within human alveolar macrophages in non-acidified organelles that… Expand

Human lymphocytes contain NTPDase (NTPDase-1; ecto-apyrase; ecto-diphosphohydrolase; CD39; EC 3.6.1.5), a cation-dependent enzyme… Expand

The tubuloglomerular feedback response, the change in afferent arteriolar tone caused by a change in NaCl concentration at the… Expand

Ecto-nucleotidases play a pivotal role in terminating the signalling via ATP and in producing adenosine, a neuromodulator in the… Expand

Publisher Summary This chapter discusses the molecular structures, catalytic properties, and functional roles of ecto… Expand

We investigated the expression and function of P2 receptors and ecto-nucleotidases on human monocyte derived dendritic cells (DC… Expand

The human ecto-apyrase gene family consists of five reported members (CD39, CD39-L1,CD39-L2, CD39-L3, and CD39-L4). The family… Expand

We previously demonstrated that when platelets are in motion and in proximity to endothelial cells, they become unresponsive to… Expand

Extracellular nucleotides acting as signaling molecules are inactivated by hydrolysis catalyzed by ecto-nucleotidases. ATP is… Expand

Nucleotides such as ATP, ADP, UTP or the diadenosine polyphosphates and possibly even NAD+ are extracellular signaling substances… Expand