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EZN 2968

Known as: EZN-2968, EZN2968 
 
National Institutes of Health

Related topics

Related topics

2 relations
Anti-HIF-1alpha LNA Antisense Oligonucleotide EZN-2968

Broader (1)

Oligonucleotides

Papers overview

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2014
2014
Hypoxia inducible factor-1 alpha as a therapeutic target in multiple myeloma
The increasing importance of hypoxia-inducible factor-1α (HIF-1α) in tumorigenesis raises the possibility that agents which… Expand
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2014
2014
HIF-1α inhibition blocks the cross talk between multiple myeloma plasma cells and tumor microenvironment.
Multiple myeloma (MM) is a malignant disorder of post-germinal center B cells, characterized by the clonal proliferation of… Expand
Highly Cited
2013
Highly Cited
2013
Pilot trial of EZN-2968, an antisense oligonucleotide inhibitor of hypoxia-inducible factor-1 alpha (HIF-1α), in patients with refractory solid tumors
AbstractPurpose Hypoxia-inducible factor-1 (HIF-1) facilitates the adaptation of normal and tumor tissues to oxygen deprivation… Expand
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2013
2013
Abstract 95: Inhibiiton of non-hypoxic HIF-1 expression in letrozole-resistant breast cancer cells reduces their cancer stem cell characteristics.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Although aromatase inhibitors (AIs) have been shown… Expand
2011
2011
Abstract LB-407: Down-modulation of mRNA by EZN-2968, an hypoxia-inducible factor-1α (HIF-1α) mRNA antagonist, administered in adult patients with advanced solid tumors
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Background : HIF-1 is a transcription factor that is a… Expand
2009
2009
EZN-2968, a novel hypoxia-inducible factor-1α (HIF-1α) messenger ribonucleic acid (mRNA) antagonist: Results of a phase I, pharmacokinetic (PK), dose-escalation study of daily administration in…
2564 Background: HIF-1 is a transcription factor that regulates expression of many key genes, notably those switching cell… Expand
Highly Cited
2008
Highly Cited
2008
A RNA antagonist of hypoxia-inducible factor-1α, EZN-2968, inhibits tumor cell growth
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that plays a critical role in angiogenesis, survival, metastasis… Expand
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2008
2008
398 POSTER Phase I, pharmacokinetic (PK), dose-escalation study of EZN-2968, a novel hypoxia-inducible factor-1 alpha (HIF-1a) antagonist, administered weekly in patients (pts) with solid tumours
 
2008
2008
Inhibition of hypoxia inducible factor-1 α (HIF-1α) by an RNA antagonist, EZN-2968, in vitro and in vivo.
1570 Inhibition of hypoxia inducible factor-1 α (HIF-1α) by an RNA antagonist, EZN-2968, in vitro and in vivo. 1Enzon… Expand
Review
1972
Review
1972
The zeta function of toral endomorphisms
In this note we give a completely elementary way to compute the number of fixed points of a certain class of toral endomorphisms… Expand
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