ESC/E(Z) complex

Known as: PRC2 complex, ESC/E(Z) complex location, Extra Sex Combs/Enhancer of Zeste complex location 
A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2003-2017
010203020032017

Papers overview

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Highly Cited
2013
Highly Cited
2013
Chromatin modifications have been implicated in the self-renewal and differentiation of embryonic stem cells (ESCs). However, the… (More)
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Highly Cited
2013
Highly Cited
2013
Two recurrent mutations, K27M and G34R/V, within histone variant H3.3 were recently identified in ∼50% of pHGGs. Both mutations… (More)
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Highly Cited
2012
Highly Cited
2012
Long non-coding RNAs (lncRNAs) are a numerous class of newly discovered genes in the human genome, which have been proposed to be… (More)
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Highly Cited
2010
Highly Cited
2010
EZH2, the catalytic subunit of the PRC2 complex, catalyzes the mono- through trimethylation of lysine 27 on histone H3 (H3K27… (More)
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Highly Cited
2010
Highly Cited
2010
In placental mammals, inactivation of one of the X chromosomes in female cells ensures sex chromosome dosage compensation. The 17… (More)
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Highly Cited
2008
Highly Cited
2008
Recent investigations have implicated long antisense noncoding RNAs in the epigenetic regulation of chromosomal domains. Here we… (More)
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Highly Cited
2008
Highly Cited
2008
Trimethylation on H3K27 (H3K27me3) mediated by Polycomb repressive complex 2 (PRC2) has been linked to embryonic stem cell (ESC… (More)
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Highly Cited
2008
Highly Cited
2008
Polycomb group proteins are critical to maintaining gene repression established during Drosophila development. Part of this group… (More)
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Highly Cited
2007
Highly Cited
2007
The trithorax and the polycomb group proteins are chromatin modifiers, which play a key role in the epigenetic regulation of… (More)
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2003
2003
Polycomb group (PcG) proteins are required to maintain stable repression of the homeotic genes and others throughout development… (More)
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