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SummaryBackground ES-285 (spisulosine) is a novel compound derived from the marine mollusk Spisula polynoma with evidence of… Expand An improved four-step approach for the stereoselective synthesis of long-chain anti-2-amino-3-alkanols is described. Using this… Expand SummaryBackground ES-285 (Spisulosine) is a novel marine compound with antitumor activity in preclinical studies. A phase I study… Expand A dose-escalation, phase I study evaluated the safety, pharmacokinetics, pharmacogenomics, and efficacy of ES-285, a novel agent… Expand During the past decades, intense attention has been focused on the anti-tumor properties of marine compounds which some of them… Expand The chemical, biological and ecological diversity of the marine ecosystem has contributed immensely in the discovery of extremely… Expand 4111 Introduction: ES-285 is a novel anti-cancer agent originally isolated from the North Atlantic Clam, Spisula polynyma… Expand Nature has been instrumental as a source for therapeutics. Despite the fact that we live in an oceanic planet, a number of… Expand Chromophor and fluorophor addition reactions involving phenylisothiocyanate (PITC) and dansyl chloride (DC) were optimized to… Expand A method was developed for the quantitative analysis of the novel anticancer agent ES-285 (spisulosine; free base) in human… Expand