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ERN1 protein, human

Known as: IRE1 protein, human, Ire1-alpha, Endoplasmic Reticulum-To-Nucleus Signaling 1 
Serine/threonine-protein kinase/endoribonuclease IRE1 (977 aa, ~110 kDa) is encoded by the human ERN1 gene. This protein is involved in both protein… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Endoplasmic reticulum (ER)-mediated protein secretion and quality control have been shown to play an important role in immune… Expand
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Review
2011
Review
2011
The unfolded protein response (UPR) is activated upon the accumulation of misfolded proteins in the endoplasmic reticulum (ER… Expand
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Highly Cited
2011
Highly Cited
2011
IRE1 plays an essential role in the endoplasmic reticulum (ER) stress response in yeast and mammals. We found that a double… Expand
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Highly Cited
2011
Highly Cited
2011
The endoplasmic reticulum (ER) is the cellular organelle responsible for protein folding and assembly, lipid and sterol… Expand
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Highly Cited
2009
Highly Cited
2009
Maintenance of endoplasmic reticulum (ER) function is achieved in part through Ire1 (inositol-requiring enzyme 1), a… Expand
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Highly Cited
2009
Highly Cited
2009
The endoplasmic reticulum (ER) is a key organelle involved in sensing and responding to stressful conditions, including those… Expand
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Highly Cited
2009
Highly Cited
2009
Epidemiologic and laboratory studies suggest that paraquat can be an environmental etiologic factor in Parkinson's disease (PD… Expand
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Highly Cited
2008
Highly Cited
2008
The biogenesis of endoplasmic reticulum (ER) exit sites (ERES) involves the formation of phosphatidylinositol-4 phosphate (PI4… Expand
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Review
1999
Review
1999
In eukaryotic cells, accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER) leads to a stress response… Expand
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Highly Cited
1998
Highly Cited
1998
Eukaryotes respond to the presence of unfolded protein in the endoplasmic reticulum (ER) by up-regulating the transcription of… Expand
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