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EREG protein, human

Known as: EREG, Epiregulin, epiregulin protein, human 
Epiregulin (49 aa, ~6 kDa) is encoded by the human EREG gene. This protein is involved in the positive regulation of cell proliferation.
National Institutes of Health

Related topics

Related topics

12 relations
Cell Proliferation Regulatory ProcessEGF-Like DomainERBB Family Signaling PathwayERBB4 Signaling Pathway

Broader (1)

Epiregulin

Papers overview

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2017
2017
EGFR Ligands Have Differential Effects on Dimer Stability and Signaling.
EREG and EPGN induce weak EGFR dimerization but sustained signaling compared with EGF. 
2016
2016
THE EFFECT OF TBX2 AND EPIREGULIN ON SIGNAL TRANSDUCTION PATHWAYS IN THE MCF10A HUMAN BREAST EPITHELIAL CELL LINE
2016
2016
Молекулярные маркеры чувствительности и резистентности карцином толстой кишки к терапии антагонистами EGFR
Targeted therapy of metastatic colorectal cancer lacks predictive markers with positive predictive value, i.e. the selection of… 
2014
2014
Mapping Functional Epitopes of Dengue Virus E2 DIII for Binding to Broadly-Neutralizing Antibody 4E11
Characterization of the EGFR signaling in acquired endocrine resistance using an MCF7 in vitro model Julia L. Alba, Esther A… 
2013
2013
Mutation Status of KRAS, BRAF, PIK3CA and Expression Level of AREG and EREG Identify Responders to Cetuximab in a Large Panel of Patient Derived Colorectal Carcinoma Xenografts of All Four UICC…
To advance preclinical testing of novel targeted drugs in colorectal cancer (CRC) we established a panel of 133 mouse xenograft… 
2012
2012
Inflammation: The gut takes a toll on liver cancer
Schwabe and colleagues show that PAMPs and intestinal bacteria promote TLR4 signalling in the liver, which promotes liver tumour… 
2012
2012
Cornea Important Role of Epiregulin in Inflammatory Responses during Corneal Epithelial Wound Healing
METHODS. A 2-mm diameter central epithelial wound was created in epiregulin-KO and wild-type (WT) mouse corneas. The size of the… 
2010
2010
Abstract 3612: Potent preclinical anti-tumor activity of MGCD265, an orally active Met/VEGFR multitargeted kinase inhibitor in Phase II clinical development, in combination with an EGFR inhibitor
MGCD265 is an oral multitargeted receptor tyrosine kinase inhibitor in Phase II clinical development. MGCD265 targets the Met… 
2003
2003
Epiregulin as a major autocrine/paracrine factor released from the ERK- and p38MAPK-activated vascular smooth muscle cells
2003
2003
NMR structure of human Epiregulin