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ERBB2 Interacting Protein, Human

Known as: Densin-180-Like Protein, Erbb2-Interacting Protein, ERBB2IP protein, human 
Protein LAP2 (1412 aa, ~158 kDa) is encoded by the human ERBIN gene. This protein plays a role in the modulation of receptor tyrosine kinase… Expand
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
Erbin is a member of the LAP (leucine-rich repeat (LRR) and PDZ domain) family. It inhibits Ras-mediated activation of ERK in… Expand
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Highly Cited
2006
Highly Cited
2006
ABSTRACT Intracellular peptidoglycan (PG) recognition in human cells is mediated by the NACHT-LRR proteins Nod1 and Nod2… Expand
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Highly Cited
2005
Highly Cited
2005
By constructing stably transfected cells harboring the same amount of epidermal growth factor (EGF) receptor (EGFR), but with… Expand
Highly Cited
2005
Highly Cited
2005
Biallelic mutations in the neurofibromatosis 2 (NF2) gene are linked to schwannoma and meningioma tumorigenesis. Cells with NF2… Expand
Highly Cited
2003
Highly Cited
2003
The LAP (leucine-rich repeatand PDZ-containing) family of proteins play a role in maintaining epithelial and neuronal cell size… Expand
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Highly Cited
2003
Highly Cited
2003
Erbin contains a class I PDZ domain that binds to the C-terminal region of the receptor tyrosine kinase ErbB2, a class II ligand… Expand
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Highly Cited
2003
Highly Cited
2003
We present evidence here that Erbin is a negative regulator of the Ras-Raf-Erk signaling pathway. Expression of Erbin decreases… Expand
Highly Cited
2002
Highly Cited
2002
Erbin is a recently described member of the LAP (leucine-rich repeat and PDZ domain) protein family. We used a C-terminally… Expand
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Highly Cited
2001
Highly Cited
2001
Identification of protein complexes associated with the ERBB2/HER2 receptor may help unravel the mechanisms of its activation and… Expand
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Highly Cited
2000
Highly Cited
2000
The ERBB receptors have a crucial role in morphogenesis and oncogenesis. We have identified a new PDZ protein we named ERBIN… Expand
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