Skip to search formSkip to main contentSkip to account menu

EPHA4 protein, human

Known as: EC 2.7.1.112, Receptor Protein-Tyrosine Kinase HEK8, TYRO1 Protein Tyrosine Kinase 
Ephrin type-A receptor 4 (986 aa, ~110 kDa) is encoded by the human EPHA4 gene. This protein plays a role in neuronal morphology, cell-cell signaling… 
National Institutes of Health

Related topics

Related topics

28 relations
Axon GuidanceCell Differentiation processCell ProliferationEPHA4 gene

Broader (2)

EphB2 ReceptorProtein Tyrosine Kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting motor neurons. Disease onset and progression… 
Highly Cited
2009
Highly Cited
2009
Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport
Astrocytes are critical participants in synapse development and function, but their role in synaptic plasticity is unclear. Eph… 
Highly Cited
2004
Highly Cited
2004
Axonal Regeneration and Lack of Astrocytic Gliosis in EphA4-Deficient Mice
Spinal cord injury usually results in permanent paralysis because of lack of regrowth of damaged neurons. Here we demonstrate… 
Highly Cited
2004
Highly Cited
2004
Hippocampal plasticity requires postsynaptic ephrinBs
Chemical synapses contain specialized pre- and postsynaptic structures that regulate synaptic transmission and plasticity. EphB… 
Highly Cited
2003
Highly Cited
2003
Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling
Communication between glial cells and neurons is emerging as a critical parameter of synaptic function. However, the molecular… 
Highly Cited
2001
Highly Cited
2001
Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control.
Growing axons follow highly stereotypical pathways, guided by a variety of attractive and repulsive cues, before establishing… 
Highly Cited
2001
Highly Cited
2001
Kinase-Dependent and Kinase-Independent Functions of EphA4 Receptors in Major Axon Tract Formation In Vivo
Highly Cited
2000
Highly Cited
2000
Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone
The subventricular zone (SVZ) of the lateral ventricles, the largest remaining germinal zone of the adult mammalian brain… 
Highly Cited
1998
Highly Cited
1998
EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract.
Members of the Eph family of tyrosine kinase receptors have been implicated in the regulation of developmental processes and, in… 
Highly Cited
1998
Highly Cited
1998
Eph signaling is required for segmentation and differentiation of the somites.
Somitogenesis involves the segmentation of the paraxial mesoderm into units along the anteroposterior axis. Here we show a role… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)