EMD 53998

Known as: EMD-53998, Quinoline, 6-(3,6-dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-1-(3,4-dimethoxybenzoyl)-1,2,3,4-tetrahydro- 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2005
012319912005

Papers overview

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2005
2005
Background. Most positive inotropic agents increase cardiac contractility by increasing the amount of Ca2 cycled with each beat… (More)
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Review
1998
Review
1998
Congestive heart failure (CHF) is a common cardiovascular disorder that is characterised, in part, by a decreased cardiac output… (More)
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1997
1997
Positive inotropic compounds may be harmful in the long-term treatment of chronic congestive heart failure because they may… (More)
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1996
1996
The effect of EMD-53998 (EMD) on elementary steps of the cross-bridge cycle in skinned porcine myocardium was studied to… (More)
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1996
1996
We investigated the effects of EMD-53998 and digoxin on Ca2+ transients and left ventricular (LV) function in indo 1-loaded… (More)
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1996
1996
We investigated the effect of a new Ca++ sensitizer, MCI-154, which is known to increase myofibrillar Ca++ sensitivity and… (More)
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1995
1995
We have developed a novel method for measuring steady-state force-[Ca2+]i relations in isolated, membrane-intact rat trabeculae… (More)
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1993
1993
EMD 53998 (a thiadiazinone) is a novel inotropic substance that increases the Ca2+ sensitivity of the myofilaments in skinned… (More)
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1992
1992
BACKGROUND Most positive inotropic agents increase cardiac contractility by increasing the amount of Ca2+ cycled with each beat… (More)
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1991
1991
EMD 53998 (a thiadiazinone) is an inotropic drug that produces a pronounced increase in the Ca2+ sensitivity of the contractile… (More)
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