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EMD 21388
Known as:
EMD-21388
National Institutes of Health
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1997
1997
Different Tissue Distribution, Elimination, and Kinetics of Thyroxine and Its Conformational Analog, the Synthetic Flavonoid EMD 49209 in the Rat1.
J. P. Schro der-van der Elst
,
D. van der Heide
,
H. Rokos
,
J. Ko Hrle
,
G. Morreale de Escobar
Endocrinology
1997
Corpus ID: 631672
The synthetic flavonoids EMD 23188 and EMD 49209, developed as T4 analogs, displace T4 from transthyretin, and in vitro they…
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1992
1992
Thyroxine (T4) transport and distribution in rats treated with EMD 21388, a synthetic flavonoid that displaces T4 from transthyretin.
C. Mendel
,
R. Cavalieri
,
J. Köhrle
Endocrinology
1992
Corpus ID: 34567895
To test whether plasma transthyretin (TTR) might play a specific direct role in the transfer of T4 from the plasma to tissues, in…
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Highly Cited
1990
Highly Cited
1990
Flavonoid administration immediately displaces thyroxine (T4) from serum transthyretin, increases serum free T4, and decreases serum thyrotropin in the rat.
W. Lueprasitsakul
,
S. Alex
,
+4 authors
L. Braverman
Endocrinology
1990
Corpus ID: 22118766
Naturally occurring and synthetic plant flavonoids, such as EMD 21388, are potent inhibitors of thyroid hormone 5'-deiodinase (5…
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Highly Cited
1989
Highly Cited
1989
Rapid effects of the flavonoid EMD 21388 on serum thyroid hormone binding and thyrotropin regulation in the rat.
J. Köhrle
,
S. L. Fang
,
+5 authors
L. Braverman
Endocrinology
1989
Corpus ID: 8360698
Naturally occurring and synthetic flavonoids are potent inhibitors of thyroid hormone 5'-deiodination and binding to human serum…
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1988
1988
Flavonoid effects on transport, metabolism and action of thyroid hormones.
J. Köhrle
,
M. Spanka
,
K. Irmscher
,
R. Hesch
Progress in clinical and biological research
1988
Corpus ID: 31686111
Flavonoids are potent non-toxic ITH deiodinase inhibitors in microsomal membranes, and intact rat hepatocytes. Flavonoids are…
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