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EIF2B4 protein, human

Known as: EIF2B4, Eukaryotic Translation Initiation Factor 2B, Delta, EIF2B Delta 
Translation initiation factor eIF-2B subunit delta (523 aa, ~58 kDa) is encoded by the human EIF2B4 gene. This protein plays a role in both guanine… Expand
National Institutes of Health

Related topics

Related topics

16 relations
EIF2B1 geneEIF2B1 protein, humanEIF2B2 geneEIF2B3 gene
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Structural insights into ISRIB, a memory‐enhancing inhibitor of the integrated stress response
The integrated stress response (ISR) regulates protein synthesis under conditions of stress. Phosphorylation of translation… Expand
2016
2016
rAed a 4: A New 67-kDa Aedes aegypti Mosquito Salivary Allergen for the Diagnosis of Mosquito Allergy
Background: Accurate diagnosis of mosquito allergy has been hampered by the laborious task of obtaining mosquito salivary… Expand
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Highly Cited
2015
Highly Cited
2015
Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response
The general translation initiation factor eIF2 is a major translational control point. Multiple signaling pathways in the… Expand
Highly Cited
2013
Highly Cited
2013
eIF2B promotes eIF5 dissociation from eIF2*GDP to facilitate guanine nucleotide exchange for translation initiation.
Protein synthesis factor eIF2 delivers initiator tRNA to the ribosome. Two proteins regulate its G-protein cycle: eIF5 has both… Expand
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2008
2008
Discrimination between stable and dynamic components of protein complexes by means of quantitative proteomics
To discriminate between stable and dynamic protein–protein interactions, we propose a strategy in which cells with and without… Expand
Highly Cited
2007
Highly Cited
2007
A synthetic protein approach toward accurate mass spectrometric quantification of component stoichiometry of multiprotein complexes.
Quantitative description of protein interactions is crucial to understand and model molecular systems regulating various cellular… Expand
1998
1998
Reconstitution and purification of eukaryotic initiation factor 2B (eIF2B) expressed in Sf21 insect cells.
Eukaryotic initiation factor eIF2B plays a key role in the regulation of protein synthesis through its ability to catalyze the… Expand
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