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EIF2B1 protein, human

Known as: Eukaryotic Translation Initiation Factor 2B, EIF2B-Alpha, Eukaryotic Translation Initiation Factor 2B, Alpha 
Translation initiation factor eIF-2B subunit alpha (305 aa, ~34 kDa) is encoded by the human EIF2B1 gene. This protein plays a role in both the… Expand
National Institutes of Health

Related topics

Related topics

17 relations
EIF2B1 geneEIF2B2 geneEIF2B3 geneEIF2B4 gene
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Broader (1)

Eukaryotic Initiation Factor-2, beta Subunit

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
eIF2 and the control of cell physiology.
Eukaryotic initiation factor eIF2 and its 'exchange factor' eIF2B play a key role in the regulation of protein synthesis in… Expand
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Highly Cited
2002
Highly Cited
2002
TNF-alpha impairs heart and skeletal muscle protein synthesis by altering translation initiation.
This study examined potential mechanisms contributing to the inhibition of protein synthesis in skeletal muscle and heart after… Expand
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Highly Cited
2002
Highly Cited
2002
TNF-α impairs heart and skeletal muscle protein synthesis by altering translation initiation
This study examined potential mechanisms contributing to the inhibition of protein synthesis in skeletal muscle and heart after… Expand
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Highly Cited
2002
Highly Cited
2002
Role of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta signaling pathway.
The phosphatidylinositol 3-kinase (PI 3-kinase)/Akt signaling pathway is an important mediator of growth factor-dependent… Expand
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Highly Cited
2000
Highly Cited
2000
Acute attenuation of translation initiation and protein synthesis by glucocorticoids in skeletal muscle.
Glucocorticoids are diabetogenic factors that not only antagonize the action of insulin in target tissues but also render these… Expand
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Highly Cited
2000
Highly Cited
2000
Phosphorylation of serine 51 in initiation factor 2 alpha (eIF2 alpha) promotes complex formation between eIF2 alpha(P) and eIF2B and causes inhibition in the guanine nucleotide exchange activity of…
Phosphorylation of serine 51 residue on the alpha-subunit of eukaryotic initiation factor 2 (eIF2alpha) inhibits the guanine… Expand
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Highly Cited
2000
Highly Cited
2000
Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR
PKR is a double-stranded (ds) RNA activated protein kinase whose expression is induced by interferon. Activated PKR… Expand
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Highly Cited
1998
Highly Cited
1998
Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin.
Eukaryotic initiation factor eIF2B catalyses a key regulatory step in mRNA translation. eIF2B and total protein synthesis are… Expand
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Review
1997
Review
1997
Molecular mechanisms for the control of translation by insulin.
Insulin acutely stimulates protein synthesis in mammalian cells, and this involves activation of the process of mRNA translation… Expand
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Highly Cited
1996
Highly Cited
1996
Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2.
Eukaryotic translation initiation factor 2B (eIF2B) is a five-subunit complex that catalyzes guanine nucleotide exchange on eIF2… Expand
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