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EIF2B1 protein, human
Known as:
Eukaryotic Translation Initiation Factor 2B
, EIF2B-Alpha
, Eukaryotic Translation Initiation Factor 2B, Alpha
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Translation initiation factor eIF-2B subunit alpha (305 aa, ~34 kDa) is encoded by the human EIF2B1 gene. This protein plays a role in both the…
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National Institutes of Health
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Related topics
Related topics
17 relations
EIF2B1 gene
EIF2B2 gene
EIF2B3 gene
EIF2B4 gene
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Broader (1)
Eukaryotic Initiation Factor-2, beta Subunit
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
eIF2 and the control of cell physiology.
C. Proud
Seminars in cell & developmental biology
2005
Corpus ID: 30700985
Highly Cited
2002
Highly Cited
2002
Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter
M. S. van der Knaap
,
P. Leegwater
,
+5 authors
J. Pronk
Annals of neurology
2002
Corpus ID: 1849575
Leukoencephalopathy with vanishing white matter is a recently defined autosomal recessive disorder. The course is chronic…
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Highly Cited
2002
Highly Cited
2002
TNF-α impairs heart and skeletal muscle protein synthesis by altering translation initiation
C. Lang
,
R. Frost
,
A. Nairn
,
D. MacLean
,
T. Vary
2002
Corpus ID: 43078086
This study examined potential mechanisms contributing to the inhibition of protein synthesis in skeletal muscle and heart after…
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Highly Cited
2002
Highly Cited
2002
Role of Translation Initiation Factor 2B in Control of Cell Survival by the Phosphatidylinositol 3-Kinase/Akt/Glycogen Synthase Kinase 3β Signaling Pathway
M. Pap
,
G. Cooper
Molecular and Cellular Biology
2002
Corpus ID: 32263973
ABSTRACT The phosphatidylinositol 3-kinase (PI 3-kinase)/Akt signaling pathway is an important mediator of growth factor…
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Highly Cited
2000
Highly Cited
2000
Phosphorylation of serine 51 in initiation factor 2 alpha (eIF2 alpha) promotes complex formation between eIF2 alpha(P) and eIF2B and causes inhibition in the guanine nucleotide exchange activity of…
A. Sudhakar
,
A. Ramachandran
,
S. Ghosh
,
S. E. Hasnain
,
R. Kaufman
,
K. Ramaiah
Biochemistry
2000
Corpus ID: 26440875
Phosphorylation of serine 51 residue on the alpha-subunit of eukaryotic initiation factor 2 (eIF2alpha) inhibits the guanine…
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Highly Cited
2000
Highly Cited
2000
Acute attenuation of translation initiation and protein synthesis by glucocorticoids in skeletal muscle.
O. Shah
,
S. Kimball
,
L. Jefferson
American journal of physiology. Endocrinology and…
2000
Corpus ID: 8948417
Glucocorticoids are diabetogenic factors that not only antagonize the action of insulin in target tissues but also render these…
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Highly Cited
1998
Highly Cited
1998
Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase‐3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin
G. Welsh
,
Christa M Miller
,
A. Loughlin
,
N. Price
FEBS letters
1998
Corpus ID: 29189093
Review
1997
Review
1997
Molecular mechanisms for the control of translation by insulin.
C. Proud
,
R. Denton
The Biochemical journal
1997
Corpus ID: 33314857
Insulin acutely stimulates protein synthesis in mammalian cells, and this involves activation of the process of mRNA translation…
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Review
1994
Review
1994
The guanine nucleotide-exchange factor, eIF-2B.
N. Price
,
C. Proud
Biochimie
1994
Corpus ID: 44736042
Highly Cited
1985
Highly Cited
1985
Adenovirus VAI RNA prevents phosphorylation of the eukaryotic initiation factor 2 alpha subunit subsequent to infection.
R. Schneider
,
B. Safer
,
S. Munemitsu
,
C. Samuel
,
T. Shenk
Proceedings of the National Academy of Sciences…
1985
Corpus ID: 37057742
The virus-associated VAI RNA of adenovirus is a small, RNA polymerase III-transcribed species required for efficient translation…
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