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EGIS 3886

Known as: EGIS-3886, EGIS3886 
National Institutes of Health

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deramciclane

Papers overview

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2010
2010
Distribution of deramciclane (EGIS-3886) in rat brain regions
SummaryThe time related distribution and pharmacokinetics of double-labelled EGIS-3886 (EGIS-3886-phenyl-14C and-ethyl-3H) were… 
2007
2007
Comparison of the effects of deramciclane, ritanserin and buspirone on extracellular dopamine and its metabolites in striatum and nucleus accumbens of freely moving rats.
In the present study, we assessed the effect of single graded doses of a putative anxiolytic compound, the 5-HT(2A/C )antagonist… 
1999
1999
Differential EEG effects of the anxiolytic drugs, deramciclane (EGIS-3886), ritanserin and chlordiazepoxide in rats
Abstract The influence of serotonergic and benzodiazepine type anxiolytic drugs on the cortical activation and sleep-wakefulness… 
1999
1999
Whole‐body Autoradiography and Quantitative Organ‐level Distribution Study of Deramciclane in Rats
The distribution of 3H‐labelled deramciclane (EGIS‐3886), a new 5‐HT2 antagonist with anxiolytic activity, has been investigated… 
1999
1999
Stereochemistry and enantiomeric purity of a novel anxiolytic agent, deramciclane fumarate.
The synthesis, stereostructure, and enantiomeric separation by chromatography of a new, chiral anxiolytic agent, deramciclane… 
1999
1999
[Investigation of the physico-chemical properties of deramciclane (EGIS-3886), a new anxiolytic compound. Ionization and lipophilicity].
Ionization and lipophilicity of deramciclane hydrogenfumarate (EGIS-3886), a novel anxiolytic compound being under clinical trial… 
1998
1998
Absorption of the new anxiolytic compound deramciclane in rats, dogs and rabbits.
The absorption of deramciclane fumarate ((1R,2S,4R)-(-)-N,N-dimethyl-2-[(1,7,7-trimethyl-2-phenylbicyclo [2,2,1] hept-2-yl) oxy… 
1998
1998
Pharmacokinetics of deramciclane in rabbits.
The pharmacokinetics of deramciclane (CAS 120444-78-8, EGIS-3886) was investigated in rabbits after i.v., p.o. and s.c… 
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