EGEN-001

Known as: phIL-12-005/PPC, Nanoparticle-encased IL-12 DNA Plasmid Vector, GEN-1 
A nanoparticle-based formulation composed of a non-viral plasmid DNA vector encoding the human pro-inflammatory cytokine interleukin-12 (IL-12… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
MicroRNAs (miRNA) aberrantly expressed in tumors may offer novel therapeutic approaches to treatment. miR-145 is downregulated in… (More)
Is this relevant?
Highly Cited
2008
Highly Cited
2008
The success of nucleic acid therapies depends upon delivery vehicle’s ability to selectively and efficiently deliver therapeutic… (More)
  • figure 1
  • figure 2
  • figure 5
  • figure 4
  • figure 6
Is this relevant?
Highly Cited
2007
Highly Cited
2007
PURPOSE To prospectively evaluate whether use of combined radiofrequency ablation (RFA) and percutaneous ethanol injection (PEI… (More)
Is this relevant?
Highly Cited
2006
Highly Cited
2006
The goals of this study were as follows: 1) to evaluate the efficacy of different polyethylenimine (PEI) structures for siRNA… (More)
  • figure 2
  • figure 1
  • figure 3
  • figure 4
  • table I
Is this relevant?
Highly Cited
2004
Highly Cited
2004
BACKGROUND Inactivity is a leading contributor to chronic health problems. Here, we examined the effects of a pedometer-based… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Purpose. Polyethylenimine (PEI) is a highly effective gene delivery vector, but because it is an off-the shelf material, its… (More)
  • table I
  • table II
  • figure 1
  • figure 3
  • figure 2
Is this relevant?
Highly Cited
2002
Highly Cited
2002
During animal development, organ size is determined primarily by the amount of cell proliferation, which must be tightly… (More)
  • figure 1
  • figure 2
  • figure 4
  • figure 3
  • figure 5
Is this relevant?
Highly Cited
2002
Highly Cited
2002
BACKGROUND Systemic administration of linear polyethylenimine-DNA complexes (L-PEI/DNA) results in transient expression of the… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Previously, we showed that the eradication of murine hepatic metastatic colon carcinomas was achieved by using a combination… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Along with the analysis of color features in HSV space, a new dividing method to quantize the color space into 36 non-uniform… (More)
  • figure 4
Is this relevant?