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E-selectin Antagonist GMI-1271

Known as: GMI-1271 
A synthetic, glycomimetic molecule and E-selectin (CD62E) antagonist, with potential anti-thrombotic, antineoplastic and chemopotentiating activities… 
National Institutes of Health

Papers overview

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2019
2019
Alliance A041701 - a Randomized Phase 2/3 Study of Conventional Chemotherapy +/- Uproleselan (GMI-1271) in Older Adults with Acute Myeloid Leukemia (AML) Receiving Intensive Induction Chemotherapy
Uproleselan (GMI-1271) is a novel antagonist of E-selectin, an adhesion molecule expressed on endothelial cells. E-selectin is… 
2017
2017
GMI-1271, a novel E-selectin antagonist, combined with induction chemotherapy in elderly patients with untreated AML.
2560Background: The outcomes for elderly patients (pts) with acute myeloid leukemia (AML) remain poor, therefore newer and less… 
2017
2017
GMI-1271, a novel E-selectin antagonist, in combination with chemotherapy in relapsed/refractory AML.
2520Background: GMI-1271 is a novel antagonist of E-selectin (E-sel) that down-regulates cell survival pathways and enhances… 
2016
2016
A Phase I/II Study of GMI-1271, a Novel E-Selectin Antagonist, in Combination with Induction Chemotherapy in Relapsed/Refractory and Elderly Previously Untreated Acute Myeloid Leukemia; Results to…
Background The treatment of patients with relapsed acute myeloid leukemia (AML) remains a significant challenge with poor… 
2016
2016
Pancreatic Cancer Invasion of the Lymphatic Vasculature and Contributions of the Tumor Microenvironment: Roles for E-selectin and CXCR4
As the fourth leading cause of cancer-related deaths, pancreatic cancer is one of the most lethal forms of cancers in the United… 
2015
2015
E-Selectin Ligand Expression Increases with Progression of Myeloma and Induces Drug Resistance in a Murine Transplant Model, Which Is Overcome By the Glycomimetic E-Selectin Antagonist, GMI-1271
There is increasing evidence that E-selectin and its ligands play an important role in the progression of multiple myeloma (MM… 
2014
2014
Mobilisation of Reconstituting HSC Is Boosted By Synergy Between G-CSF and E-Selectin Antagonist GMI-1271.
![Graphic][1] We have previously identified a novel function for the adhesion molecule E-selectin – awakening otherwise dormant… 
2014
2014
Abstract 4503: A small molecule glycomimetic antagonist of E-selectin (GMI-1271) prevents pancreatic tumor metastasis and offers a novel treatment for improved efficacy of chemotherapy
The processes of intra- and extravasation of tumor cells into and out of the blood and lymphatic systems are crucial steps during… 
2014
2014
Magic mirror in my hand, which is the lineage in the end? A case of acute leukemia with hand-mirror cells.
![Figure][1] A 75-year-old man with a diagnosis of chronic myelomonocytic leukemia evolved with asthenia and worsening… 
2012
2012
Novel E-Selectin Antagonist GMI-1271 Decreases Venous Thrombosis without Increased Bleeding Potential in a Mouse Model
Abstract 3422 Introduction: Selectins function in venous thrombosis presumably by binding and activating immune cells to… 
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