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E 6080

Known as: E-6080, E6080 
 
National Institutes of Health

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Broader (1)

Thiazoles

Papers overview

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1995
1995
Inhibition of leukotriene C4 and B4 release by human eosinophils with the new 5-lipoxygenase inhibitor 6-hydroxy-2(4-sulfamoylbenzylamino)-4,5,7-trimethylbenzothiazo le hydrochloride.
Eosinophils generate and release leukotrienes C4 and B4 (LTC4, LTB4) and platelet activating factor (PAF), all of which have the… Expand
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1995
1995
Eicosanoid and cytokine production by human peritoneal macrophages : characterization and modulation
textabstractThe human body has an extensive and specialized cellular network to defend against invading microorganisms, and to… Expand
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1994
1994
Interactions between cytokines and eicosanoids: a study using human peritoneal macrophages.
To examine the interactions between the main pro-inflammatory cytokines and eicosanoids produced by human inflammatory cells… Expand
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1994
1994
Phorbol ester-induced dermal inflammation in mice: evaluation of inhibitors of 5-lipoxygenase and antagonists of leukotriene B4 receptor.
In the present investigation, the effects of selective inhibitors of 5-lipoxygenase (5-LO), zileuton and TZI-41127, E-6080, AA… Expand
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1993
1993
The effects of anti-PAF and other agents on the nasal symptoms in sensitized guinea pigs.
To define the role of platelet activating factor (PAF) in allergic rhinitis, we examined the effects of anti-PAF agents (WEB2086… Expand
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1993
1993
Inhibition of IgE-mediated leukotriene generation and bronchoconstriction in primates with a new 5-lipoxygenase inhibitor, E6080.
The inhibitory effects of a novel compound, 6-hydroxy-2-(4-sulfamoylbenzylamino)-4,5,7-trimethylbenzothiazo le hydrochloride… Expand
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1992
1992
Species difference and tissue distribution of uridine diphosphate-glucuronyltransferase activities toward E6080, 1-naphthol and 4-hydroxybiphenyl.
The apparent in vitro kinetic constants of uridine diphosphate-glucuronyltransferase (UDP-GT) activities towards E6080, 1… Expand
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1991
1991
Determination of plasma leukotrienes in antigen-induced bronchoconstrictive guinea pigs.
Convenient extraction and radioimmunoassay methods for measurement of leukotrienes C4 and D4 (LTC4 and LTD4) in biological fluids… Expand
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1991
1991
Effect of a novel 5-lipoxygenase inhibitor, E6080 on bronchospasm, airway cellular infiltration and leukotriene production in guinea pigs.
6-Hydroxy-2-(4-sulfamoylbenzylamino)-4,5,7-trimethylbenzothiazo le hydrochloride (E6080), an orally active and selective 5… Expand
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1990
1990
Involvement of leukotriene C4 in PAF-induced death in mice.
The role of leukotrienes (LTs) in the pathogenesis of platelet-activating factor (PAF)-induced death in mice was reinvestigated… Expand
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