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E-52862

 
National Institutes of Health

Papers overview

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2019
2019
Osteoarthritis is the most common musculoskeletal disease worldwide, often characterized by degradation of the articular… Expand
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2018
2018
Sigma-1 receptor (σ1R) knockout (KO) CD1 mice, generated by homologous recombination, and separate pharmacological studies in… Expand
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2017
2017
This trial assessed the efficacy of MR309 (a novel selective sigma-1 receptor ligand previously developed as E-52862) in… Expand
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2017
2017
Background: E‐52862 (S1RA, 4‐[2‐[[5‐methyl‐1‐(2‐naphthalenyl)‐1H‐pyrazol‐3‐yl]oxy]ethyl]‐morpholine), a novel selective sigma 1… Expand
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2016
2016
E-52862 is a selective σ1R antagonist currently undergoing phase II clinical trials for neuropathic pain and represents a… Expand
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2015
2015
Background E-52862 is a Sigma-1 receptor antagonist (S1RA) currently under investigation as a potential analgesic medicine. We… Expand
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2014
2014
We have previously shown that the selective sigma-1 receptor (σ1 R) antagonist S1RA (E-52862) inhibits neuropathic pain and… Expand
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2014
2014
The therapeutic potential of S1RA (E-52862), a selective sigma-1 receptor (σ1R) antagonist, has been explored in experimental… Expand
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2013
2013
While opioids are potent analgesics widely used in the management of pain, a number of well-known adverse effects limit their use… Expand
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2012
2012
The synthesis and pharmacological activity of a new series of 1-arylpyrazoles as potent σ(1) receptor (σ(1)R) antagonists are… Expand
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