E-52862

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2012-2018
01220122018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Sigma-1 receptor (σ1R) knockout (KO) CD1 mice, generated by homologous recombination, and separate pharmacological studies in… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2017
2017
BACKGROUND E-52862 (S1RA, 4-[2-[[5-methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]-morpholine), a novel selective sigma 1… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2016
2016
E-52862 is a selective σ1R antagonist currently undergoing phase II clinical trials for neuropathic pain and represents a… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2015
2015
BACKGROUND E-52862 is a Sigma-1 receptor antagonist (S1RA) currently under investigation as a potential analgesic medicine. We… (More)
  • table 1
  • figure 1
  • table 2
  • table 3
  • figure 2
Is this relevant?
Review
2015
Review
2015
INTRODUCTION The sigma-1 receptor (σ1R) is a ligand-regulated molecular chaperone that interacts with other proteins, including… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
2014
2014
The therapeutic potential of S1RA (E-52862), a selective sigma-1 receptor (σ1R) antagonist, has been explored in experimental… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
2014
2014
We have previously shown that the selective sigma-1 receptor (σ1 R) antagonist S1RA (E-52862) inhibits neuropathic pain and… (More)
Is this relevant?
2013
2013
While opioids are potent analgesics widely used in the management of pain, a number of well-known adverse effects limit their use… (More)
Is this relevant?
Review
2013
Review
2013
INTRODUCTION Sigma receptors are involved in several central nervous system (CNS) disorders, including mood disorders (depression… (More)
Is this relevant?
2012
2012
The synthesis and pharmacological activity of a new series of 1-arylpyrazoles as potent σ(1) receptor (σ(1)R) antagonists are… (More)
Is this relevant?