Dynemicin

An antitumor antibiotic of the enediyne class. It has demonstrated high DNA cleavage activity in the presence of NADPH, antimicrobial and tumor… (More)
National Institutes of Health

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2012
2012
Biosynthesis of the enediyne natural product dynemicin in Micromonospora chersina is initiated by DynE8, a highly reducing… (More)
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2010
2010
Dynemicins are structurally related 10-membered enediyne natural products isolated from Micromonospora chernisa with potent… (More)
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2004
2004
Prodrugs of dynemicin analogs were synthesized, and their activation by aldolase antibody (Ab) 38C2 was evaluated by DNA-cleaving… (More)
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2003
2003
A universal PCR method for the rapid amplification of minimal enediyne polyketide synthase (PKS) genes and the application of… (More)
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2003
2003
During the past decade there has been a dramatic increase in research effort directed toward the isolation and evaluation of… (More)
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1995
1995
RNA cleavage by enediyne anticancer antibiotics was shown to occur with no apparent sequence selectivity, but RNA structure… (More)
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1994
1994
The naturally occurring enediyne antibiotics, which include calicheamicin, esperamicin, neocarzinostatin, kedarcidin and… (More)
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1992
1992
The rational design and biological actions of a new class of DNA-cleaving molecules with potent and selective anticancer activity… (More)
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1991
1991
A specific interaction of stable branched DNA molecules with the antitumor antibiotic dynemicin is reported. Dynemicin contains… (More)
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1990
1990
Dynemicin is a hybrid containing anthraquinone and enediyne cores, which contribute to binding and cleavage of DNA, respectively… (More)
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