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Dynemicin

An antitumor antibiotic of the enediyne class. It has demonstrated high DNA cleavage activity in the presence of NADPH, antimicrobial and tumor… 
National Institutes of Health

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NCIt Antineoplastic Agent Terminology

Papers overview

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2019
2019
A letter from Professor Samuel J. Danishefsky
2003
2003
Simplified dynemicin analogues: diastereoselective synthesis and evaluation of their activity against plasmid DNA.
The total synthesis of two diastereoisomeric simplified dynemicin analogues is reported. The key steps involved are: the regio… 
2000
2000
High Level Quantum-Chemical Computations on the Cyclizations of Enyne Allenes
The ring-closure reactions of the enediyne and enyne-allene moieties of the natural antitumor antibiotics neocarzinostatin (1… 
1998
1998
Progress towards the total synthesis of a spermine-conjugated dynemicin analog
Progress towards the synthesis of the spermine-conjugated Dynemicin analog 4 is described. The synthetic route starts with the… 
1995
1995
Two [7.3.1]azabicyclo-z-3-ene-1,5-diyne analogues of dynemicin A.
The crystal structures of methyl 6-methoxy-17-oxo-2-azatricyclo[7.7.1.0(3,8)]heptadeca-3(8),4 ,6,13-tetraene- 11,15-diyne-2… 
1994
1994
Regulation of apoptosis in leukemic cells by analogs of dynemicin A.
1993
1993
Conformation-selective DNA strand breaks by dynemicin: a molecular wedge into flexible regions of DNA.
We present evidence that the enediyne antitumor antibiotic dynemicin recognizes and cleaves conformationally flexible regions of… 
1991
1991
Site-specific interaction of the antitumor antibiotic dynemicin with branched DNA molecules.
A specific interaction of stable branched DNA molecules with the antitumor antibiotic dynemicin is reported. Dynemicin contains… 
1991
1991
Drug binding to a DNA BZ molecule: analysis by chemical footprinting.
The polymorphism in a DNA 16-mer (designated BZ-II) has been investigated by means of circular dichroism (CD) spectroscopy and… 
1989
1989
DNA binding and cleavage by enediyne antitumor antibiotics, esperamicin and dynemicin.
Esperamicin A1 and dynemicin represent a new class of DNA binding/damaging agents characterized by unique ten-membered ene-diyne… 
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