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Dup 128

Known as: Dup-128, Dup128 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

lecimibide

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2002
2002
Selective uptake from LDL is stimulated by unsaturated fatty acids and modulated by cholesterol content in the plasma membrane: role of plasma membrane composition in regulating non-SR-BI-mediated…
We previously reported that unsaturated fatty acids stimulated low-density lipoprotein (LDL) particle uptake in J774 macrophages… 
1999
1999
ApoB100 secretion from HepG2 cells is decreased by the ACAT inhibitor CI-1011: an effect associated with enhanced intracellular degradation of ApoB.
The concept that hepatic cholesteryl ester (CE) mass and the rate of cholesterol esterification regulate hepatocyte assembly and… 
Highly Cited
1998
Highly Cited
1998
Immunodepletion experiments suggest that acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) protein plays a major catalytic role in adult human liver, adrenal gland, macrophages, and kidney, but…
The first acyl-coenzyme A:cholesterol acyltransferase (ACAT) cDNA cloned and expressed in 1993 is designated as ACAT-1. In… 
1998
1998
Inhibition of cholesterol esterification by DuP 128 decreases hepatic apolipoprotein B secretion in vivo: effect of dietary fat and cholesterol.
1995
1995
Effect of membrane environment on inhibition of acyl-CoA:cholesterol acyltransferase by a range of synthetic inhibitors.
1995
1995
Evaluation of cultured hamster hepatocytes as an experimental model for the study of very low density lipoprotein secretion.
1994
1994
Pharmacokinetics and pharmacodynamics of the ACAT inhibitor DuP128 in man
Highly Cited
1994
Highly Cited
1994
Effect of the acyl‐CoA: cholesterol acyltransferase inhibitor DuP 128 on cholesterol absorption and serum cholesterol in humans
Intestinal cholesterol esterification by the enzyme acyl‐CoA:cholesterol acyltransferase (ACAT) is a presumed prerequisite for… 
Highly Cited
1994
Highly Cited
1994
Inhibition of hepatic ACAT decreases ApoB secretion in miniature pigs fed a cholesterol-free diet.
To test the hypothesis that hepatic cholesteryl ester is involved in the regulation of apolipoprotein (apo) B secretion into… 
1993
1993
Bile acid synthesis in hamster hepatocytes in primary culture: sources of cholesterol and comparison with other species.
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