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DuP 734

Known as: DuP-734, Ethanone, 2-(1-(cyclopropylmethyl)-4-piperidinyl)-1-(4-fluorophenyl)-, hydrobromide 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (4)

Anti-Arrhythmia AgentsAntipsychotic AgentsPiperidinesSerotonin Antagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2000
2000
[Anti-arrhythmic effect of the sigma-receptor blocker DuP 734 in ischemia and myocardial reperfusion].
It has been found that in vivo pretreatment of rats with the sigma receptor antagonist DuP 734 (1 mg/kg) resulted in an increase… 
2000
2000
[The use of delta-receptor antagonist DuP 734 for correction of the contractile diastolic cardiac dysfunction in reperfusion injury and oxidative stress].
Intraperitoneal administration of the sigma-receptor antagonist DuP 734 (1 mg/kg) 15 min before heart excision produces a… 
2000
2000
Z-IQNP: a potential radioligand for SPECT imaging of muscarinic acetylcholine receptors in Alzheimer’s disease
Abstract Rationale: The density of the M2 subtype of muscarinic acetylcholine receptors (mAChR) has been shown to be reduced in… 
1999
1999
Ligands for opioid and sigma-receptors improve cardiac electrical stability in rat models of post-infarction cardiosclerosis and stress.
1997
1997
[The anti-arrhythmic effect of the selective sigma-receptor antagonist DuP 734 [1-(cyclopropylmethyl)-4-(2'-(4''-fluorophenyl)-2'-oxoethyl)piper idine HBr]].
It was demonstrated on models of epinephrine-, CaCl2-, and aconitine-induced arrhythmias that the sigma-receptor antagonist… 
1995
1995
Dose and species dependent pharmacokinetics of a novel sigma receptor antagonist, DuP 734.
The pharmacokinetics of a novel sigma receptor antagonist, DuP 734, was evaluated in mice, rats, beagle dogs and cynomolgus… 
1994
1994
Determination of a novel sigma receptor antagonist, DuP 734, in rat plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection.
1994
1994
Piperidinyltetralin sigma ligands.
Sigma receptor ligands have been proposed to be potential antipsychotic drugs based on their activity profile in animal… 
1992
1992
Autoradiographic identification and characterization of σ receptors in guinea pig brain using [3H]1(cyclopropylmethyl)-4-(2′-(4≈-fluorophenyl)-2′-oxoethyl) piperidine ([3H]DuP 734), a novel…
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