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DprE1 protein, Mycobacterium tuberculosis
Known as:
decaprenyl-phosphoryl-beta-D-ribofuranose oxidoreductase DprE1, M tuberculosis
, decaprenylphosphoryl-beta-D-ribose2'-epimerase, Mycobacterium tuberculosis
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Alcohol Oxidoreductases
Bacterial Proteins
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Determinants of the Inhibition of DprE 1 and CYP 2 C 9 by Antitubercular Thiophenes
Xiao-xuan Lyu
,
Sarah MBatt
,
+11 authors
Feng Wang
2017
Corpus ID: 54212502
Mycobacterium tuberculosis (Mtb) DprE1, an essential isomerase for the biosynthesis of the mycobacterial cell wall, is a…
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Review
2016
Review
2016
New and Old Hot Drug Targets in Tuberculosis.
L. Chiarelli
,
Giorgia Mori
,
Marta Espósito
,
B. Orena
,
M. Pasca
Current Medicinal Chemistry
2016
Corpus ID: 25830465
Tuberculosis is an infectious disease caused by the bacillus Mycobacterium tuberculosis. The World Health Organization publishes…
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Highly Cited
2013
Highly Cited
2013
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis
Feng Wang
,
Dhinakaran Sambandan
,
+24 authors
P. Schultz
Proceedings of the National Academy of Sciences
2013
Corpus ID: 25738417
Significance The global problem of TB has worsened in recent years with the emergence of drug-resistant organisms, and new drugs…
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Highly Cited
2013
Highly Cited
2013
Azaindoles: noncovalent DprE1 inhibitors from scaffold morphing efforts, kill Mycobacterium tuberculosis and are efficacious in vivo.
Pravin S. Shirude
,
R. Shandil
,
+36 authors
M. Chatterji
Journal of Medicinal Chemistry
2013
Corpus ID: 43728299
We report 1,4-azaindoles as a new inhibitor class that kills Mycobacterium tuberculosis in vitro and demonstrates efficacy in…
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