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DprE1 protein, Mycobacterium tuberculosis
decaprenyl-phosphoryl-beta-D-ribofuranose oxidoreductase DprE1, M tuberculosis
, decaprenylphosphoryl-beta-D-ribose2'-epimerase, Mycobacterium tuberculosis
National Institutes of Health
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Determinants of the Inhibition of DprE 1 and CYP 2 C 9 by Antitubercular Thiophenes
Corpus ID: 54212502
Mycobacterium tuberculosis (Mtb) DprE1, an essential isomerase for the biosynthesis of the mycobacterial cell wall, is a…
New and Old Hot Drug Targets in Tuberculosis.
B. S. Orena
Current medicinal chemistry
Corpus ID: 25830465
Tuberculosis is an infectious disease caused by the bacillus Mycobacterium tuberculosis. The World Health Organization publishes…
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis
Proceedings of the National Academy of Sciences
Corpus ID: 25738417
Significance The global problem of TB has worsened in recent years with the emergence of drug-resistant organisms, and new drugs…
Azaindoles: noncovalent DprE1 inhibitors from scaffold morphing efforts, kill Mycobacterium tuberculosis and are efficacious in vivo.
Pravin S. Shirude
Journal of medicinal chemistry
Corpus ID: 43728299
We report 1,4-azaindoles as a new inhibitor class that kills Mycobacterium tuberculosis in vitro and demonstrates efficacy in…
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