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Double Homeobox Protein 4
Known as:
DUX4
, Double Homeobox Protein 10
, Double Homeobox Protein 4/10
Double homeobox protein 4 (424 aa, ~45 kDa) is encoded by the human DUX4 gene. This protein plays a role in the regulation of transcription.
National Institutes of Health
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Related topics
Related topics
6 relations
Cell Nucleus
DUX4 gene
Genes, Regulator
Homeodomain Proteins
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Embryonic factor helps tumours to lie low
U. Harjes
Nature Reviews. Cancer
2019
Corpus ID: 199474070
Chew et al. demonstrate that re-expression of the early embryonic transcription factor DUX4 might contribute to mechanisms of…
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2019
2019
Stratification and prognosis of IGH-DUX4 positive acute lymphoblastic leukemia in children
J. Müller
,
B. Fedders
,
+7 authors
M. Stanulla
Klinische Pädiatrie
2019
Corpus ID: 196566671
2018
2018
Abstract 1485: Allelic specificity of immunoglobulin heavy chain (IGH) translocation in B-cell acute lymphoblastic leukemia (B-ALL) unveiled by long-read sequencing
Liqing Tian
,
Beisi Xu
,
+10 authors
Jinghui Zhang
Molecular and Cellular Biology / Genetics
2018
Corpus ID: 57079120
Translocation that juxtaposes the IGH@ enhancer (Eμ) to a proto-oncogene such as CRLF2, EPOR and DUX4 is a common oncogenic…
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2016
2016
DUX 4 induces a transcriptome more characteristic of a less-differentiated cell state and inhibits myogenesis
P. Knopp
,
Y. Krom
,
+5 authors
P. Zammit
2016
Corpus ID: 1700165
Skeletal muscle wasting in facioscapulohumeral muscular dystrophy (FSHD) results in substantial morbidity. On a disease…
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2016
2016
Dux4 controls migration of mesenchymal stem cells through the Cxcr4-Sdf1 axis
Petr Dmitriev
,
E. Kiseleva
,
+11 authors
Y. Vassetzky
OncoTarget
2016
Corpus ID: 3517011
We performed transcriptome profiling of human immortalized myoblasts (MB) transiently expressing double homeobox transcription…
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2016
2016
High Frequency Hearing Loss and Hyperactivity in DUX4 Transgenic Mice
A. Dandapat
,
B. Perrin
,
+5 authors
M. Kyba
PLoS ONE
2016
Corpus ID: 6922950
Facioscapulohumeral muscular dystrophy (FSHD) is caused by mutations leading to ectopic expression of the transcription factor…
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2016
2016
Mouse Dux is myotoxic and shares partial functional homology with its human paralog DUX4.
J. Eidahl
,
C. Giesige
,
+6 authors
S. Harper
Human Molecular Genetics
2016
Corpus ID: 40394020
D4Z4 repeats are present in at least 11 different mammalian species, including humans and mice. Each repeat contains an open…
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2015
2015
The Role of D4Z4-Encoded Proteins in the Osteogenic Differentiation of Mesenchymal Stromal Cells Isolated from Bone Marrow.
Laurence de la Kethulle de Ryhove
,
E. Ansseau
,
+8 authors
A. Belayew
Stem Cells and Development
2015
Corpus ID: 21821169
Facioscapulohumeral muscular dystrophy (FSHD) is associated with an activation of the double homeobox 4 (DUX4) gene, which we…
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2015
2015
UPF 1 DUX NMD in Facioscapulohumeral Muscular Dystrophy
2015
Corpus ID: 55235067
Next generation sequencing has revolutionized the field of human genetics, and discovery of disease causing mutations continues…
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2005
2005
Intracellular trafficking and dynamics of double homeodomain proteins.
C. Ostlund
,
Ruth M Garcia-Carrasquillo
,
A. Belayew
,
H. Worman
Biochemistry
2005
Corpus ID: 26787194
Double homeodomain (DUX) proteins are encoded by a family of 3.3-kilobase repeated elements dispersed in the human genome. One of…
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