Dornase Alfa

Known as: Dornase alfa, recombinant, Deoxyribonuclease (human clone 18-1 protein moiety), recombinant human dnase 
A recombinant human deoxyribonuclease I (rhDNAse) with selective DNA cleaving activity. Upon intrapleural administration, dornase alfa catalyzes the… (More)
National Institutes of Health

Papers overview

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Review
2013
Review
2013
BACKGROUND Inhalation of the enzyme dornase alfa reduces sputum viscosity and improves clinical outcomes of people with cystic… (More)
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Highly Cited
2011
Highly Cited
2011
Outcome measures to assess therapeutic interventions in cystic fibrosis (CF) patients with mild lung disease are lacking. Our aim… (More)
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Review
2010
Review
2010
BACKGROUND Dornase alfa is currently used to treat pulmonary disease (the major cause of morbidity and mortality) in cystic… (More)
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2005
2005
OBJECTIVE To determine the benefit of nasally inhaled dornase alfa in patients with cystic fibrosis and nasal symptoms. DESIGN… (More)
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2005
2005
PURPOSES To evaluate quantitative air trapping measurements in children with mild cystic fibrosis (CF) lung disease during a 1… (More)
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2002
2002
Leukocytes that infiltrate cystic fibrosis (CF) sputum as a result of infection have long been known to liberate large amounts of… (More)
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Highly Cited
2001
Highly Cited
2001
OBJECTIVE Our objective was to determine whether long-term treatment of young patients with cystic fibrosis (CF) with dornase… (More)
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1998
1998
Aerosolized recombinant human DNase (dornase alfa) reduces mucus viscoelasticity in vitro and improves pulmonary function in… (More)
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Review
1995
Review
1995
The major causes of morbidity and mortality in cystic fibrosis (CF) are the obstruction and damaged airways that result from the… (More)
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Highly Cited
1994
Highly Cited
1994
BACKGROUND Respiratory disease in patients with cystic fibrosis is characterized by airway obstruction caused by the accumulation… (More)
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