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Dominant Negative Receptor

Known as: Dominant-Negative Receptor 
A receptor protein that inhibits the downstream functions of an associated receptor, which requires dimerization for activity. The dominant-negative… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2017
051019912017

Related topics

Related topics

3 relations
Ligand BindingReceptor GeneReceptor Signaling

Related mentions per year

Related mentions per year

1965-2018
1960198020002020
Dominant Negative Receptor
Ligand Binding
Receptor Signaling
Receptor Gene

Papers overview

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Highly Cited
2006
Highly Cited
2006
Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival.
Malignant gliomas remain incurable brain tumors because of their diffuse-invasive growth. So far, the genetic and molecular… (More)
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Highly Cited
2005
Highly Cited
2005
Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers.
Notch3 is a member of an evolutionarily conserved family of cell surface receptors important in cell-fate determination in both… (More)
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Highly Cited
2003
Highly Cited
2003
Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1).
Large clonal expansions of peripheral CD8+ T cells carrying receptors for single epitopes of CMV and EBV are common in the… (More)
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2002
2002
A secreted soluble form of ApoE receptor 2 acts as a dominant-negative receptor and inhibits Reelin signaling.
Specialized neurons throughout the developing central nervous system secrete Reelin, which binds to ApoE receptor 2 (ApoER2) and… (More)
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2001
2001
Truncated trkB.T1 is dominant negative inhibitor of trkB.TK+-mediated cell survival.
Truncated trkB.T1 (T1) neurotrophin receptor inhibits full-length trkB.TK+ (TK+) signaling. At least two possible mechanisms have… (More)
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Highly Cited
2001
Highly Cited
2001
Interleukin 6 inhibits proliferation and, in cooperation with an epidermal growth factor receptor autocrine loop, increases migration of T47D breast cancer cells.
Interleukin (IL)-6, a multifunctional regulator of immune response, hematopoiesis, and acute phase reactions, has also been shown… (More)
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Highly Cited
1998
Highly Cited
1998
Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning.
Despite a wealth of experimental data implicating fibroblast growth factor (FGF) signaling in various developmental processes… (More)
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Highly Cited
1998
Highly Cited
1998
A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer.
The 5-year survival rate for women with metastatic breast cancer is only 25-30%; thus, the need to improve treatment is apparent… (More)
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Highly Cited
1994
Highly Cited
1994
eFGF regulates Xbra expression during Xenopus gastrulation.
We show that, in addition to a role in mesoderm induction during blastula stages, FGF signalling plays an important role in… (More)
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Highly Cited
1993
Highly Cited
1993
Functional inhibition of retinoic acid response by dominant negative retinoic acid receptor mutants.
The diverse effects of retinoids on the development, growth, and homeostasis of vertebrate organisms are mediated in part by… (More)
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