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Dominant Negative Receptor

Known as: Dominant-Negative Receptor 
A receptor protein that inhibits the downstream functions of an associated receptor, which requires dimerization for activity. The dominant-negative… Expand
National Institutes of Health

Related topics

Related topics

3 relations
Ligand BindingReceptor GeneReceptor Signaling

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition.
Following immune attack, solid tumors upregulate coinhibitory ligands that bind to inhibitory receptors on T cells. This adaptive… Expand
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Review
2012
Review
2012
Truncated TrkB: beyond a dominant negative receptor.
  • B. M. Fenner
  • Cytokine & growth factor reviews
  • 2012
    • Corpus ID: 1629460
BDNF activates trkB receptors to regulate neuronal survival, differentiation, and proliferation. Mutations in the BDNF gene… Expand
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Highly Cited
2006
Highly Cited
2006
Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival.
Malignant gliomas remain incurable brain tumors because of their diffuse-invasive growth. So far, the genetic and molecular… Expand
Highly Cited
2005
Highly Cited
2005
Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers.
Notch3 is a member of an evolutionarily conserved family of cell surface receptors important in cell-fate determination in both… Expand
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Highly Cited
2003
Highly Cited
2003
Brain-derived neurotrophic factor in the ventral midbrain–nucleus accumbens pathway: a role in depression
BACKGROUND Previous work has shown that brain-derived neurotrophic factor (BDNF) and its receptor, tyrosine kinase receptor B… Expand
Highly Cited
1998
Highly Cited
1998
Soluble dominant‐negative receptor uncovers essential roles for fibroblast growth factors in multi‐organ induction and patterning
Despite a wealth of experimental data implicating fibroblast growth factor (FGF) signaling in various developmental processes… Expand
Highly Cited
1998
Highly Cited
1998
A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer.
The 5-year survival rate for women with metastatic breast cancer is only 25-30%; thus, the need to improve treatment is apparent… Expand
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Highly Cited
1994
Highly Cited
1994
eFGF regulates Xbra expression during Xenopus gastrulation.
We show that, in addition to a role in mesoderm induction during blastula stages, FGF signalling plays an important role in… Expand
Highly Cited
1993
Highly Cited
1993
Functional inhibition of retinoic acid response by dominant negative retinoic acid receptor mutants.
The diverse effects of retinoids on the development, growth, and homeostasis of vertebrate organisms are mediated in part by… Expand
Review
1991
Review
1991
Estrogen receptor variants in clinical breast cancer.
We have used the screening techniques of chemical mismatch cleavage, single stranded conformational polymorphism, and gel… Expand
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