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Dominant Negative Receptor

Known as: Dominant-Negative Receptor 
A receptor protein that inhibits the downstream functions of an associated receptor, which requires dimerization for activity. The dominant-negative… Expand
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Following immune attack, solid tumors upregulate coinhibitory ligands that bind to inhibitory receptors on T cells. This adaptive… Expand
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Review
2012
Review
2012
  • B. M. Fenner
  • Cytokine & growth factor reviews
  • 2012
  • Corpus ID: 1629460
BDNF activates trkB receptors to regulate neuronal survival, differentiation, and proliferation. Mutations in the BDNF gene… Expand
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Highly Cited
2006
Highly Cited
2006
Malignant gliomas remain incurable brain tumors because of their diffuse-invasive growth. So far, the genetic and molecular… Expand
Highly Cited
2005
Highly Cited
2005
Notch3 is a member of an evolutionarily conserved family of cell surface receptors important in cell-fate determination in both… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Previous work has shown that brain-derived neurotrophic factor (BDNF) and its receptor, tyrosine kinase receptor B… Expand
Highly Cited
1998
Highly Cited
1998
Despite a wealth of experimental data implicating fibroblast growth factor (FGF) signaling in various developmental processes… Expand
Highly Cited
1998
Highly Cited
1998
The 5-year survival rate for women with metastatic breast cancer is only 25-30%; thus, the need to improve treatment is apparent… Expand
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Highly Cited
1994
Highly Cited
1994
We show that, in addition to a role in mesoderm induction during blastula stages, FGF signalling plays an important role in… Expand
Highly Cited
1993
Highly Cited
1993
The diverse effects of retinoids on the development, growth, and homeostasis of vertebrate organisms are mediated in part by… Expand
Review
1991
Review
1991
We have used the screening techniques of chemical mismatch cleavage, single stranded conformational polymorphism, and gel… Expand