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Dominant Negative Receptor
Known as:
Dominant-Negative Receptor
A receptor protein that inhibits the downstream functions of an associated receptor, which requires dimerization for activity. The dominant-negative…
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National Institutes of Health
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Related topics
Related topics
3 relations
Ligand Binding
Receptor Gene
Receptor Signaling
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition.
L. Cherkassky
,
A. Morello
,
+5 authors
P. Adusumilli
The Journal of clinical investigation
2016
Corpus ID: 12059497
Following immune attack, solid tumors upregulate coinhibitory ligands that bind to inhibitory receptors on T cells. This adaptive…
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Review
2012
Review
2012
Truncated TrkB: beyond a dominant negative receptor.
B. Fenner
Cytokine & growth factor reviews
2012
Corpus ID: 1629460
Highly Cited
2006
Highly Cited
2006
Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival.
P. Vajkoczy
,
P. Knyazev
,
+9 authors
A. Ullrich
Proceedings of the National Academy of Sciences…
2006
Corpus ID: 31555018
Malignant gliomas remain incurable brain tumors because of their diffuse-invasive growth. So far, the genetic and molecular…
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Highly Cited
2003
Highly Cited
2003
Brain-derived neurotrophic factor in the ventral midbrain–nucleus accumbens pathway: a role in depression
A. Eisch
,
C. Bolaños
,
+5 authors
E. Nestler
Biological Psychiatry
2003
Corpus ID: 24589781
Highly Cited
2003
Highly Cited
2003
Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1)
Q. Ouyang
,
Wolfgang M. Wagner
,
+6 authors
G. Pawelec
Experimental Gerontology
2003
Corpus ID: 44591282
Highly Cited
1998
Highly Cited
1998
Soluble dominant‐negative receptor uncovers essential roles for fibroblast growth factors in multi‐organ induction and patterning
G. Celli
,
W. Larochelle
,
S. Mackem
,
R. Sharp
,
G. Merlino
The EMBO journal
1998
Corpus ID: 14475415
Despite a wealth of experimental data implicating fibroblast growth factor (FGF) signaling in various developmental processes…
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Highly Cited
1998
Highly Cited
1998
A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer.
S. Dunn
,
M. Ehrlich
,
+5 authors
J. C. Barrett
Cancer research
1998
Corpus ID: 9956458
The 5-year survival rate for women with metastatic breast cancer is only 25-30%; thus, the need to improve treatment is apparent…
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Review
1998
Review
1998
Dual functions of the heartless fibroblast growth factor receptor in development of the Drosophila embryonic mesoderm.
A. Michelson
,
S. Gisselbrecht
,
Y. Zhou
,
K. Baek
,
E. Buff
Developmental genetics
1998
Corpus ID: 46584424
The Drosophila embryonic mesoderm forms by invagination of the ventral-most blastoderm cells. Subsequent development of this germ…
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Review
1995
Review
1995
VEGF-mediated tumour angiogenesis: a new target for cancer therapy.
G. Martiny-Baron
,
D. Marmé
Current opinion in biotechnology
1995
Corpus ID: 45026401
Review
1991
Review
1991
Estrogen receptor variants in clinical breast cancer.
W. McGuire
,
G. Chamness
,
S. Fuqua
Molecular endocrinology
1991
Corpus ID: 35338777
We have used the screening techniques of chemical mismatch cleavage, single stranded conformational polymorphism, and gel…
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