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Dominant Negative Receptor

Known as: Dominant-Negative Receptor 
A receptor protein that inhibits the downstream functions of an associated receptor, which requires dimerization for activity. The dominant-negative… 
National Institutes of Health

Related topics

Related topics

3 relations
Ligand BindingReceptor GeneReceptor Signaling

Papers overview

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Highly Cited
2016
Highly Cited
2016
Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition.
Following immune attack, solid tumors upregulate coinhibitory ligands that bind to inhibitory receptors on T cells. This adaptive… 
Review
2012
Review
2012
Truncated TrkB: beyond a dominant negative receptor.
  • B. Fenner
  • Cytokine & growth factor reviews
  • 2012
  • Corpus ID: 1629460
Highly Cited
2006
Highly Cited
2006
Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival.
Malignant gliomas remain incurable brain tumors because of their diffuse-invasive growth. So far, the genetic and molecular… 
Highly Cited
2003
Highly Cited
2003
Brain-derived neurotrophic factor in the ventral midbrain–nucleus accumbens pathway: a role in depression
Highly Cited
2003
Highly Cited
2003
Age-associated accumulation of CMV-specific CD8+ T cells expressing the inhibitory killer cell lectin-like receptor G1 (KLRG1)
Highly Cited
1998
Highly Cited
1998
Soluble dominant‐negative receptor uncovers essential roles for fibroblast growth factors in multi‐organ induction and patterning
Despite a wealth of experimental data implicating fibroblast growth factor (FGF) signaling in various developmental processes… 
Highly Cited
1998
Highly Cited
1998
A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer.
The 5-year survival rate for women with metastatic breast cancer is only 25-30%; thus, the need to improve treatment is apparent… 
Review
1998
Review
1998
Dual functions of the heartless fibroblast growth factor receptor in development of the Drosophila embryonic mesoderm.
The Drosophila embryonic mesoderm forms by invagination of the ventral-most blastoderm cells. Subsequent development of this germ… 
Review
1995
Review
1995
VEGF-mediated tumour angiogenesis: a new target for cancer therapy.
Review
1991
Review
1991
Estrogen receptor variants in clinical breast cancer.
We have used the screening techniques of chemical mismatch cleavage, single stranded conformational polymorphism, and gel… 
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