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Dominant Negative Receptor

Known as: Dominant-Negative Receptor 
A receptor protein that inhibits the downstream functions of an associated receptor, which requires dimerization for activity. The dominant-negative… Expand
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Following immune attack, solid tumors upregulate coinhibitory ligands that bind to inhibitory receptors on T cells. This adaptive… Expand
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Review
2012
Review
2012
BDNF activates trkB receptors to regulate neuronal survival, differentiation, and proliferation. Mutations in the BDNF gene… Expand
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Review
2008
Review
2008
The constitutive activation of β-catenin-dependent (‘canonical’) Wnt signalling is a necessary initiating event in the genesis of… Expand
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Highly Cited
2006
Highly Cited
2006
Malignant gliomas remain incurable brain tumors because of their diffuse-invasive growth. So far, the genetic and molecular… Expand
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Highly Cited
2005
Highly Cited
2005
Notch3 is a member of an evolutionarily conserved family of cell surface receptors important in cell-fate determination in both… Expand
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Highly Cited
1998
Highly Cited
1998
Despite a wealth of experimental data implicating fibroblast growth factor (FGF) signaling in various developmental processes… Expand
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Highly Cited
1998
Highly Cited
1998
The 5-year survival rate for women with metastatic breast cancer is only 25-30%; thus, the need to improve treatment is apparent… Expand
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Highly Cited
1994
Highly Cited
1994
We show that, in addition to a role in mesoderm induction during blastula stages, FGF signalling plays an important role in… Expand
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Highly Cited
1993
Highly Cited
1993
The diverse effects of retinoids on the development, growth, and homeostasis of vertebrate organisms are mediated in part by… Expand
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Review
1991
Review
1991
We have used the screening techniques of chemical mismatch cleavage, single stranded conformational polymorphism, and gel… Expand
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