Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Dominant Negative Receptor

Known as: Dominant-Negative Receptor 
A receptor protein that inhibits the downstream functions of an associated receptor, which requires dimerization for activity. The dominant-negative… Expand
National Institutes of Health

Related topics

Related topics

3 relations
Ligand BindingReceptor GeneReceptor Signaling

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition.
Following immune attack, solid tumors upregulate coinhibitory ligands that bind to inhibitory receptors on T cells. This adaptive… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
2012
Review
2012
Truncated TrkB: beyond a dominant negative receptor.
BDNF activates trkB receptors to regulate neuronal survival, differentiation, and proliferation. Mutations in the BDNF gene… Expand
  • figure 1
  • figure 2
  • table 1
  • table 2
  • table 3
Is this relevant?
Review
2008
Review
2008
The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression
The constitutive activation of β-catenin-dependent (‘canonical’) Wnt signalling is a necessary initiating event in the genesis of… Expand
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival.
Malignant gliomas remain incurable brain tumors because of their diffuse-invasive growth. So far, the genetic and molecular… Expand
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers.
Notch3 is a member of an evolutionarily conserved family of cell surface receptors important in cell-fate determination in both… Expand
  • table 1
  • figure 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning.
Despite a wealth of experimental data implicating fibroblast growth factor (FGF) signaling in various developmental processes… Expand
  • figure 1
  • table I
  • figure 2
  • figure 3
  • table II
Is this relevant?
Highly Cited
1998
Highly Cited
1998
A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer.
The 5-year survival rate for women with metastatic breast cancer is only 25-30%; thus, the need to improve treatment is apparent… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1994
Highly Cited
1994
eFGF regulates Xbra expression during Xenopus gastrulation.
We show that, in addition to a role in mesoderm induction during blastula stages, FGF signalling plays an important role in… Expand
Is this relevant?
Highly Cited
1993
Highly Cited
1993
Functional inhibition of retinoic acid response by dominant negative retinoic acid receptor mutants.
The diverse effects of retinoids on the development, growth, and homeostasis of vertebrate organisms are mediated in part by… Expand
Is this relevant?
Review
1991
Review
1991
Estrogen receptor variants in clinical breast cancer.
We have used the screening techniques of chemical mismatch cleavage, single stranded conformational polymorphism, and gel… Expand
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE