Dominant Negative Receptor

Known as: Dominant-Negative Receptor 
A receptor protein that inhibits the downstream functions of an associated receptor, which requires dimerization for activity. The dominant-negative… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2017
051019912017

Papers overview

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Highly Cited
2006
Highly Cited
2006
Malignant gliomas remain incurable brain tumors because of their diffuse-invasive growth. So far, the genetic and molecular… (More)
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Highly Cited
2005
Highly Cited
2005
Notch3 is a member of an evolutionarily conserved family of cell surface receptors important in cell-fate determination in both… (More)
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Highly Cited
2003
Highly Cited
2003
Large clonal expansions of peripheral CD8+ T cells carrying receptors for single epitopes of CMV and EBV are common in the… (More)
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2002
2002
Specialized neurons throughout the developing central nervous system secrete Reelin, which binds to ApoE receptor 2 (ApoER2) and… (More)
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2001
2001
Truncated trkB.T1 (T1) neurotrophin receptor inhibits full-length trkB.TK+ (TK+) signaling. At least two possible mechanisms have… (More)
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Highly Cited
2001
Highly Cited
2001
Interleukin (IL)-6, a multifunctional regulator of immune response, hematopoiesis, and acute phase reactions, has also been shown… (More)
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Highly Cited
1998
Highly Cited
1998
Despite a wealth of experimental data implicating fibroblast growth factor (FGF) signaling in various developmental processes… (More)
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Highly Cited
1998
Highly Cited
1998
The 5-year survival rate for women with metastatic breast cancer is only 25-30%; thus, the need to improve treatment is apparent… (More)
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Highly Cited
1994
Highly Cited
1994
We show that, in addition to a role in mesoderm induction during blastula stages, FGF signalling plays an important role in… (More)
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Highly Cited
1993
Highly Cited
1993
The diverse effects of retinoids on the development, growth, and homeostasis of vertebrate organisms are mediated in part by… (More)
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