Dominant-Negative Mutation

Known as: Dominant Negative, Dominant-Negative Mutant, Dominant-Negative Mutation Abnormality 
Any mutation that encodes an altered gene product that acts to antagonize the wild-type allele. Dominant negative mutations are characterized by a… (More)
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
Atrial fibrillation (AF) is a common cardiac arrhythmia whose molecular etiology is poorly understood. We studied a family with… (More)
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Highly Cited
2002
Highly Cited
2002
Activation of Wnt signaling through beta-catenin/TCF complexes is a key event in the development of various tumors, in particular… (More)
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Highly Cited
2000
Highly Cited
2000
Rho GTPases control a variety of cellular processes, including actin polymerization, integrin complex formation, cell adhesion… (More)
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Highly Cited
1999
Highly Cited
1999
Thiazolidinediones are a new class of antidiabetic agent that improve insulin sensitivity and reduce plasma glucose and blood… (More)
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Highly Cited
1997
Highly Cited
1997
Chondrodysplasia Grebe type (CGT) is an autosomal recessive disorder characterized by severe limb shortening and dysmorphogenesis… (More)
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Highly Cited
1995
Highly Cited
1995
Five unrelated children are described with a rare autoimmune lymphoproliferative syndrome (ALPS) characterized by massive… (More)
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Highly Cited
1995
Highly Cited
1995
Sympathetic neurons depend on nerve growth factor (NGF) for survival and die by apoptosis in its absence. We have investigated… (More)
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Highly Cited
1994
Highly Cited
1994
ANGIOGENESIS, the sprouting of capillaries from pre-existing blood vessels, is a fundamental process in the formation of the… (More)
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Highly Cited
1993
Highly Cited
1993
The Notch gene of Drosophila plays an important role in cell fate specification throughout development. To investigate the… (More)
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Review
1987
Review
1987
Molecular biologists are increasingly faced with the problem of assigning a function to genes that have been cloned. A new… (More)
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