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Dominant-Negative Mutation

Known as: Dominant Negative, Dominant-Negative Mutant, Dominant-Negative Mutation Abnormality 
Any mutation that encodes an altered gene product that acts to antagonize the wild-type allele. Dominant negative mutations are characterized by a… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
  • D. M. Thomson
  • International journal of molecular sciences
  • 2018
  • Corpus ID: 52976864
AMPK (5’-adenosine monophosphate-activated protein kinase) is heavily involved in skeletal muscle metabolic control through its… Expand
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Review
2017
Review
2017
The endoplasmic reticulum (ER) is the organelle where secretory and membrane proteins are synthesized and folded. Unfolded… Expand
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Review
2017
Review
2017
Isocitrate dehydrogenases play important roles in cellular metabolism and cancer. This review will discuss how the roles of… Expand
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Highly Cited
2003
Highly Cited
2003
The current challenge, now that two plant genomes have been sequenced, is to assign a function to the increasing number of… Expand
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Highly Cited
2002
Highly Cited
2002
Adiponectin (Ad) is a hormone secreted by adipocytes that regulates energy homeostasis and glucose and lipid metabolism. However… Expand
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Highly Cited
1999
Highly Cited
1999
Thiazolidinediones are a new class of antidiabetic agent that improve insulin sensitivity and reduce plasma glucose and blood… Expand
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Highly Cited
1996
Highly Cited
1996
Expression of vascular endothelial growth factor (VEGF) is induced in cells exposed to hypoxia or ischemia. Neovascularization… Expand
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Highly Cited
1995
Highly Cited
1995
Five unrelated children are described with a rare autoimmune lymphoproliferative syndrome (ALPS) characterized by massive… Expand
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Highly Cited
1995
Highly Cited
1995
A serine/threonine kinase, named protein kinase B (PKB)1 for its sequence homology to both protein kinase A and C, has previously… Expand
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Review
1987
Review
1987
Molecular biologists are increasingly faced with the problem of assigning a function to genes that have been cloned. A new… Expand
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