Disopyramide:PrThr:Pt:Ser/Plas:Ord

Some pharmacokinetic parameters of disopyramide in a steady-state situation were studied in 8 patients with arrhythmias. Four… (More)

Disopyramide is an effective class I antiarrhythmic drug and widely used for the treatment of arrhythmias, but it has… (More)

OBJECTIVE To examine the effects of saturable plasma binding on the pharmacokinetics of immediate-release (IR) and controlled… (More)

Electrophysiological effects, antiarrhythmic activity and kinetics of levorotatory disopyramide (R(-) DP) and racemic… (More)

The ability of activated charcoal to enhance the drug elimination of two enantiomers, R- and S-disopyramide, was compared in… (More)

A previously unrecognized beneficial drug interaction is described. Without affecting the antiarrhythmic properties of… (More)