Dihydropyrimidine Dehydrogenase Inhibitor

Known as: DPD Inhibitors, NADP Inhibitors, Dihydrothymin Dehydrogenase Inhibitors 
Any substance that inhibits dihydropyrimidine dehydrogenase, a rate limiting enzyme in the degradation of pyrimidines. Inhibition of… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1994-2017
012319942017

Papers overview

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2013
2013
Sorafenib and S-1 (one mixed formulation containing 5-FU prodrug and dihydropyrimidine dehydrogenase inhibitor) were two… (More)
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2012
2012
S-1 is a recently developed dihydropyrimidine dehydrogenase inhibitor fluoropyrimidine and has demonstrated high maximum plasma 5… (More)
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2009
2009
S-1 is an oral anticancer agent that combines tegafur, a prodrug of 5-fluorouracil (5-FU), and 5-chloro-2,4-dihydroxypyridine… (More)
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2004
2004
Purpose: Ro 09-4889 was designed to enhance the anticancer efficacy of capecitabine (Xeloda) by generating a dihydropyrimidine… (More)
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2004
2004
PURPOSE Ro 09-4889 was designed to enhance the anticancer efficacy of capecitabine (Xeloda) by generating a dihydropyrimidine… (More)
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2003
2003
Capecitabine is an orally available fluoropyrimidine and is finally converted to 5-FU selectively in tumor tissues. In our study… (More)
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2003
2003
Irinotecan plus intravenous 5-fluorouracil with leucovorin is effective against gastrointestinal cancer. S-1 is an oral… (More)
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2002
2002
BACKGROUND Conventional systemic chemotherapy currently available for patients with inoperable hepatocellular carcinoma is… (More)
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1997
1997
Dihydropyrimidine dehydrogenase (DPD) is the key enzyme of the fluorouracil (FU) catabolic pathway. We have shown that tumor… (More)
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1994
1994
5-Benzyloxybenzyluracil (BBU) is the most potent inhibitor (Ki approximately 30 nM) of dihydrouracil dehydrogenase (EC 1.3.1.2… (More)
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