Dihydropyrimidine Dehydrogenase Deficiency

Known as: Pyrimidinemia, Familial, Hereditary Thymine-Uraciluria, Thymine-Uracilurias, Hereditary 
An autosomal recessive disorder affecting DIHYDROPYRIMIDINE DEHYDROGENASE and causing familial pyrimidinemia. It is characterized by thymine… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1984-2017
02419842017

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2005
2005
Background: Dihydropyrimidine dehydrogenase (DPD) deficiency is prevalent in 3–5% of the Caucasian population; however, the… (More)
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2005
2005
Dihydropyrimidine dehydrogenase (DPD) deficiency (McKusick 274270) is a clinically heterogeneous autosomal recessive disorder of… (More)
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2004
2004
Purpose: Dihydropyrimidine dehydrogenase (DPD)-deficient cancer patients have been shown to develop severe toxicity after… (More)
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2003
2003
Dihydropyrimidine dehydrogenase (DPD) deficiency has been linked to 5-fluorouracil toxicity, but patients may present a wide… (More)
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Highly Cited
1999
Highly Cited
1999
SummaryDihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme of 5-fluorouracil (5-FU) catabolism. We… (More)
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1997
1997
Dihydropyrimidine dehydrogenase deficiency (McKusick 274270) is an autosomal recessive disorder leading to thymine-uraciluria… (More)
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1994
1994
Dihydropyrimidine dehydrogenase (DHPD; EC 1.3.1.2) deficiency (McKusick 274270; thymine-uraciluria) has been documented so far in… (More)
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1987
1987
A family with dihydropyrimidine dehydrogenase (DPD) deficiency is presented. In 3 persons a complete deficiency, and in 3 others… (More)
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1985
1985
Dihydropyrimidine dehydrogenase (EC 1.3.1.2.) deficiency has recently been described in two separate reports of four patients… (More)
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1984
1984
Three unrelated patients with excessive thymine-uraciluria due to dihydropyrimidine dehydrogenase deficiency are described… (More)
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