Dihydroorotate Dehydrogenase (Quinone), Mitochondrial, human

Known as: Dihydroorotate Dehydrogenase (Quinone), Mitochondrial, DHOdehase, EC 1.3.3.1 
Dihydroorotate dehydrogenase (quinone), mitochondrial (395 aa, ~43 kDa) is encoded by the human DHODH gene. This protein plays a role in the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1960-2017
0246819602017

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2015
2015
Malaria is one of the most significant causes of childhood mortality, but disease control efforts are threatened by resistance of… (More)
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2006
2006
Membrane-associated dihydroorotate dehydrogenase (DHODH) is an antimalarial therapeutic target without an effective inhibitor… (More)
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2006
2006
Human dihydroorotate dehydrogenase (DHODH) represents an important target for the treatment of hyperproliferative and… (More)
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2003
2003
BACKGROUND Leflunomide inhibits de novo pyrimidine synthesis by inhibiting the activity of dihydroorotic acid dehydrogenase and… (More)
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2001
2001
Brequinar and the active metabolite of leflunomide, A77 1726, have been clearly shown to inhibit human dihydroorotate… (More)
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1997
1997
Pyrimidines and purine (deoxy)nucleotides are the building blocks of DNA and RNA. Nucleoside diphosphate sugars, e.g. UDP-glucose… (More)
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1992
1992
A cDNA encoding the dihydroorotate dehydrogenase (DHOdehase; EC 1.3.3.1) of the yeast Schizosaccharomyces pombe was isolated by… (More)
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1990
1990
Little is known about the in vivo effects of inhibition of the mitochondrial pyrimidine de novo synthesis enzyme dihydroorotic… (More)
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1980
1980
A mutant yeast constitutive for synthesis of both dihydroorotic acid dehydrogenase and orotidine 5′ phosphate decarboxylase has… (More)
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1968
1968
The pathway of pyrimidine biosynthesis in Pseudomonas aeruginosa has been shown to be the same as in other bacteria. Twenty-seven… (More)
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