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Dihydroorotate Dehydrogenase (Quinone), Mitochondrial, human

Known as: Dihydroorotate Dehydrogenase (Quinone), Mitochondrial, DHOdehase, EC 1.3.3.1 
Dihydroorotate dehydrogenase (quinone), mitochondrial (395 aa, ~43 kDa) is encoded by the human DHODH gene. This protein plays a role in the… Expand
National Institutes of Health

Papers overview

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2016
2016
Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH), a key enzyme in the de novo pyrimidine biosynthesis pathway, which… Expand
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Highly Cited
2013
Highly Cited
2013
We have tested five distinct classes of established and experimental antimalarial drugs for their anticancer potential, using a… Expand
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2013
2013
Some mutations of the DHODH (dihydro-orotate dehydrogenase) gene lead to postaxial acrofacial dysostosis or Miller syndrome. Only… Expand
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2012
2012
Biallelic mutations in the gene encoding DHOdehase [dihydroorotate dehydrogenase (DHODH)], an enzyme required for de novo… Expand
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Highly Cited
2008
Highly Cited
2008
Nucleotide biosynthesis pathways have been reported to be essential in some protozoan pathogens. Hence, we evaluated the… Expand
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Highly Cited
2005
Highly Cited
2005
A series of 2-phenyl quinoline-4-carboxylic acid derivatives related to brequinar, an inhibitor of human dihydroorotate… Expand
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Highly Cited
2000
Highly Cited
2000
In animals, dihydroorotate dehydrogenase (DHODH) is a mitochondrial protein that carries out the fourth step in de novo… Expand
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Review
1999
Review
1999
Leflunomide (Arava) has recently been approved by the Food and Drug Administration for the treatment of rheumatoid arthritis (RA… Expand
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Highly Cited
1992
Highly Cited
1992
A cDNA encoding the dihydroorotate dehydrogenase (DHOdehase; EC 1.3.3.1) of the yeast Schizosaccharomyces pombe was isolated by… Expand
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Highly Cited
1968
Highly Cited
1968
The pathway of pyrimidine biosynthesis in Pseudomonas aeruginosa has been shown to be the same as in other bacteria. Twenty-seven… Expand
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