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Difluoromethylornithine

Known as: DL-alpha-Difluoromethylornithine, 2-Difluoromethylornithine, difluoromethylornithine (DFMO) 
a drug that is being studied in the treatment of cancer
National Institutes of Health

Papers overview

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Review
2013
Review
2013
Human African trypanosomiasis, or sleeping sickness, is caused by infection with parasites of the genus Trypanosoma, transmitted… Expand
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Highly Cited
2010
Highly Cited
2010
Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the… Expand
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Highly Cited
2008
Highly Cited
2008
Preclinical studies of chemoprevention drugs given in combination at low doses show remarkable efficacy in preventing adenomas… Expand
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Review
2005
Review
2005
New formulations, therapeutic switching of the established drugs amphotericin B and paromomycin, and the serendipitous discovery… Expand
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Review
2003
Review
2003
Polyamines are essential for the growth and function of normal cells. They interact with various macromolecules, both… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Although abnormal L-arginine NO signaling contributes to endothelial dysfunction in the aging cardiovascular system… Expand
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Highly Cited
2001
Highly Cited
2001
Type 2 cytokines regulate fibrotic liver pathology in mice infected with Schistosoma mansoni. Switching the immune response to a… Expand
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Review
1999
Review
1999
D,L-alpha-difluoromethylornithine (DFMO) was synthesized over 20 years ago. It was hoped that this enzyme-activated, irreversible… Expand
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Review
1993
Review
1993
African trypanosomiasis (sleeping sickness) is fatal, if untreated, and occurs in 36 African countries, south of the Sahara… Expand
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Review
1982
Review
1982
Polyamines are ubiquitous organic cations of low molecular weight. The content of these amines is closely regulated by the cell… Expand
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