Difluoromethylornithine

Known as: DL-alpha-Difluoromethylornithine, 2-Difluoromethylornithine, difluoromethylornithine (DFMO) 
a drug that is being studied in the treatment of cancer
National Institutes of Health

Topic mentions per year

Topic mentions per year

1978-2018
05010019782018

Papers overview

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Highly Cited
2008
Highly Cited
2008
Preclinical studies of chemoprevention drugs given in combination at low doses show remarkable efficacy in preventing adenomas… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Although abnormal L-arginine NO signaling contributes to endothelial dysfunction in the aging cardiovascular system… (More)
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2001
2001
PURPOSE To report the results of a prospective Phase III trial for patients with newly diagnosed glioblastoma multiforme (GBM… (More)
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2000
2000
Development of effective chemopreventive agents for human consumption requires conclusive evidence of their efficacy in animal… (More)
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Highly Cited
2000
Highly Cited
2000
Genetic knockout or pharmacological inhibition of cyclooxygenase-2 decreases the number and size of adenomas in mouse models of… (More)
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1999
1999
To be informative for chemoprevention, animal models must both closely emulate human disease and possess surrogate endpoint… (More)
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1993
1993
BACKGROUND alpha-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase (ODC), the key enzyme in… (More)
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Highly Cited
1991
Highly Cited
1991
The chemopreventive action of 40 and 80% maximum tolerated dose (MTD) levels of piroxicam, D,L-alpha-difluoromethylornithine… (More)
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Highly Cited
1990
Highly Cited
1990
The effect of three levels of piroxicam and three levels of D,L-alpha-difluoromethylornithine (DFMO) fed individually and in… (More)
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1983
1983
2-Difluoromethylornithine (DFMO) was administered to 1,2-dimethylhydrazine (DMH)-treated mice to reduce colonic polyamine levels… (More)
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