Dichloroacetate

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1956-2017
020406019562016

Papers overview

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Highly Cited
2010
Highly Cited
2010
Solid tumors, including the aggressive primary brain cancer glioblastoma multiforme, develop resistance to cell death, in part as… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE A recent landmark study demonstrated that Dichloroacetate (DCA) treatment promoted apoptosis in lung, breast, and… (More)
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Highly Cited
2007
Highly Cited
2007
The unique metabolic profile of cancer (aerobic glycolysis) might confer apoptosis resistance and be therapeutically targeted… (More)
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Highly Cited
2006
Highly Cited
2006
OBJECTIVE Open-label studies indicate that oral dichloroacetate (DCA) may be effective in treating patients with congenital… (More)
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Highly Cited
2004
Highly Cited
2004
The pulmonary arteries (PA) in pulmonary arterial hypertension (PAH) are constricted and remodeled;. They have suppressed… (More)
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Highly Cited
2003
Highly Cited
2003
Neuronal cultures in vitro readily oxidized both D-[(14)C]glucose and l-[(14)C]lactate to (14)CO(2), whereas astroglial cultures… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Chronic hypoxic pulmonary hypertension (CH-PHT) is associated with suppressed expression and function of voltage-gated… (More)
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Highly Cited
1992
Highly Cited
1992
BACKGROUND Mortality is very high in lactic acidosis, and there is no satisfactory treatment other than treatment of the… (More)
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Highly Cited
1990
Highly Cited
1990
We have previously shown that high concentrations of fatty acids depress reperfusion recovery of ischemic rat hearts as a result… (More)
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Highly Cited
1974
Highly Cited
1974
1. Monochloroacetate, dichloroacetate, trichloroacetate, difluoroacetate, 2-chloropropionate, 2,2'-dichloropropionate and 3… (More)
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