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Dacinostat

Known as: NVP-LAQ 824 
 
National Institutes of Health

Papers overview

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2019
2019
Insights into structural features of HDAC1 and its selectivity inhibition elucidated by Molecular dynamic simulation and Molecular Docking.
Histone deacetylases (HDACs) are a family of proteins whose main function is the removal of acetyl groups from lysine residues… Expand
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2019
2019
Comparison of Different Histone Deacetylase Inhibitors in Attenuating Inflammatory Pain in Rats
Histone deacetylase inhibitors (HDACIs), which interfere with the epigenetic process of histone acetylation, have shown analgesic… Expand
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2019
2019
A high-throughput screening identifies histone deacetylase inhibitors as therapeutic agents against medulloblastoma
BackgroundMedulloblastoma is the most frequently occurring malignant brain tumor in children. Current treatment strategies for… Expand
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2017
2017
Quantitative measurement of intracellular HDAC1/2 drug occupancy using a trans-cyclooctene largazole thiol probe.
Histone deacetylases (HDACs) regulate diverse cellular processes, and are promising targets for a number of diseases. Here we… Expand
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2016
2016
Transcript, methylation and molecular docking analyses of the effects of HDAC inhibitors, SAHA and Dacinostat, on SMN2 expression in fibroblasts of SMA patients
Several histone deacetylase inhibitors (HDACis) are known to increase Survival Motor Neuron 2 (SMN2) expression for the therapy… Expand
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2016
2016
A mechanistic approach to explore novel HDAC1 inhibitor using pharmacophore modeling, 3D- QSAR analysis, molecular docking, density functional and molecular dynamics simulation study.
Deregulated epigenetic activity of Histone deacetylase 1 (HDAC1) in tumor development and carcinogenesis pronounces it as… Expand
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2015
2015
Strategy for enhancing the therapeutic efficacy of histone deacetylase inhibitor dacinostat: the novel paradigm to tackle monotonous cancer chemoresistance
Histone deacetylases (HDACs) regulate gene expression by creating the closed state of chromatin via histone hypoacetylation… Expand
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Review
2012
Review
2012
Improving student's modeling framework in a tutorial-like system based on Pursuit learning automata and reinforcement learning
Intelligent Tutorial Systems are educational software packages that occupy Artificial Intelligence (AI) techniques and methods to… Expand
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2011
2011
Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.
Histone deacetylase (HDAC) inhibitors have shown promise in treating various forms of cancer. However, many HDAC inhibitors from… Expand
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2010
2010
Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824).
Inspired by natural product HDAC inhibitors, we prepared a series of conformationally restrained HDAC inhibitors based on the… Expand
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