DYRK1A gene

Known as: MNB, MNB PROTEIN KINASE, SERINE/THREONINE-SPECIFIC, DYRK1 
This gene is involved in both protein phosphorylation and signaling.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1976-2018
020406019762018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Exome sequencing studies of autism spectrum disorders (ASDs) have identified many de novo mutations but few recurrently disrupted… (More)
  • figure 1
  • table 1
  • figure 2
Is this relevant?
Highly Cited
2010
Highly Cited
2010
DYRK1A (the dual specificity tyrosine phosphorylation-regulated kinase 1A) plays an important role in body growth and brain… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2008
Highly Cited
2008
We have identified and characterized two unrelated patients with prenatal onset of microcephaly, intrauterine growth retardation… (More)
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Most individuals with Down syndrome show early onset of Alzheimer disease (AD), resulting from the extra copy of chromosome 21… (More)
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Down syndrome (DS) is the most common genetic disorder associated with mental retardation (MR). It is believed that many of the… (More)
Is this relevant?
Highly Cited
2007
Highly Cited
2007
We scanned throughout chromosome 21 to assess genetic associations with late-onset Alzheimer disease (AD) using 374 Japanese… (More)
  • figure 1
  • table 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Trisomy 21 results in Down's syndrome, but little is known about how a 1.5-fold increase in gene dosage produces the pleiotropic… (More)
  • figure 1
  • figure 5
  • table 1
  • figure 2
  • figure 4
Is this relevant?
Highly Cited
2002
Highly Cited
2002
DYRK1A is the human orthologue of the Drosophila minibrain (mnb) gene, which is involved in postembryonic neurogenesis in flies… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Down's syndrome (DS) is a major cause of mental retardation, hypotonia and delayed development. Murine models of DS carrying… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2001
Highly Cited
2001
The substrate specificity of glycogen synthase kinase 3 (GSK3) is unusual in that efficient phosphorylation only occurs if… (More)
Is this relevant?