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DYRK1A gene

Known as: MNB, MNB PROTEIN KINASE, SERINE/THREONINE-SPECIFIC, DYRK1 
This gene is involved in both protein phosphorylation and signaling.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Autism Genes, Again and Again Despite recent advances in sequencing technologies and their lowered costs—effective, highly… Expand
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Highly Cited
2010
Highly Cited
2010
Dyrk1A (dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A) is a serine/threonine kinase essential for brain… Expand
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Highly Cited
2009
Highly Cited
2009
Individuals with partial HSA21 trisomies and mice with partial MMU16 trisomies containing an extra copy of the DYRK1A gene… Expand
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Highly Cited
2007
Highly Cited
2007
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a… Expand
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Highly Cited
2007
Highly Cited
2007
Most individuals with Down syndrome show early onset of Alzheimer disease (AD), resulting from the extra copy of chromosome 21… Expand
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Highly Cited
2006
Highly Cited
2006
Trisomy 21 results in Down's syndrome, but little is known about how a 1.5-fold increase in gene dosage produces the pleiotropic… Expand
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Highly Cited
2006
Highly Cited
2006
Among the various phenotypes seen in Down syndrome (DS), mental retardation is the most common and most debilitating condition… Expand
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Highly Cited
2003
Highly Cited
2003
We have previously examined the specificities of 28 commercially available compounds, reported to be relatively selective… Expand
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Highly Cited
2002
Highly Cited
2002
ABSTRACT DYRK1A is the human orthologue of the Drosophila minibrain (mnb) gene, which is involved in postembryonic neurogenesis… Expand
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Highly Cited
2001
Highly Cited
2001
Down's syndrome (DS) is a major cause of mental retardation, hypotonia and delayed development. Murine models of DS carrying… Expand
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