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DUSP4 protein, human

Known as: Mitogen-Activated Protein Kinase Phosphatase 2, VH1-Like Phosphatase 2, MAP Kinase Phosphatase 2 
Dual specificity protein phosphatase 4 (394 aa, ~43 kDa) is encoded by the human DUSP4 gene. This protein is involved in the dephosphorylation of… Expand
National Institutes of Health

Papers overview

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2017
2017
We have reported that phosphorylation of the glucocorticoid receptor (GR) at Ser226 reduces GR nuclear translocation, resulting… Expand
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2015
2015
Over-activation of p38 is implicated in many cardiovascular diseases (CVDs), including myocardial infarction, hypertrophy, heart… Expand
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2014
2014
Redox imbalance is a primary cause of endothelial dysfunction (ED). Under oxidant stress, many critical proteins regulating… Expand
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Highly Cited
2013
Highly Cited
2013
Gain-of-function mutations in KRAS and BRAF genes are found in up to 50% of colorectal cancers. These mutations result in the… Expand
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Highly Cited
2012
Highly Cited
2012
Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer. However… Expand
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2012
2012
The MKPs (mitogen-activated protein kinase phosphatases) are a family of at least ten DUSPs (dual-specificity phosphatases) which… Expand
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2007
2007
Transcription factor E2F-1 mediates apoptosis and suppresses tumorigenesis. The mechanisms by which E2F-1 functions in these… Expand
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2007
2007
HoxA10 is a homeodomain transcription factor that is frequently overexpressed in human acute myeloid leukemia. In murine bone… Expand
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2003
2003
We sought to further elucidate signal transduction pathways for the I(1)-imidazoline receptor in PC12 cells and their interaction… Expand
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Highly Cited
2001
Highly Cited
2001
MKP-2 is a member of the mitogen-activated protein (MAP) kinase phosphatase family which has been suggested to play an important… Expand
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