DUSP4 protein, human

Known as: Mitogen-Activated Protein Kinase Phosphatase 2, VH1-Like Phosphatase 2, MAP Kinase Phosphatase 2 
Dual specificity protein phosphatase 4 (394 aa, ~43 kDa) is encoded by the human DUSP4 gene. This protein is involved in the dephosphorylation of… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2018
0246819962018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Gain-of-function mutations in KRAS and BRAF genes are found in up to 50% of colorectal cancers. These mutations result in the… (More)
  • figure 1
  • figure 2
  • figure 4
  • figure 5
  • figure 6
Is this relevant?
Highly Cited
2012
Highly Cited
2012
Neoadjuvant chemotherapy (NAC) induces a pathological complete response (pCR) in ∼30% of patients with breast cancer. However… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2008
2008
Rituximab, an anti-CD20 monoclonal antibody, has been used to treat autoimmune disorders such as mixed cryoglobulinemia (MC… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2007
2007
PURPOSE Evidence has implicated the retina as a principal controller of refractive development. In the present study, the retinal… (More)
  • table 1
Is this relevant?
2007
2007
Transcription factor E2F-1 mediates apoptosis and suppresses tumorigenesis. The mechanisms by which E2F-1 functions in these… (More)
Is this relevant?
2006
2006
Increased hepatic gluconeogenesis is an important contributor to the fasting hyperglycemia found in Type 2 diabetic patients. Low… (More)
Is this relevant?
2006
2006
The p53 tumor suppressor plays critical roles in diverse cellular responses such as cell cycle arrest, senescence, and apoptosis… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2003
2003
Extracellular signal-regulated kinase 1 (ERK1) and ERK2 (ERK1/2) dramatically enhance survival of cells exposed to heat shock… (More)
Is this relevant?
2001
2001
MKP-2 is a member of the mitogen-activated protein (MAP) kinase phosphatase family which has been suggested to play an important… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Mitogen-activated protein (MAP) kinases can be grouped into three structural families, ERK, JNK, and p38, which are thought to… (More)
Is this relevant?