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DT-5461a

 
National Institutes of Health

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DT 5461Polysaccharides

Papers overview

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2005
2005
Effect of combined administration of a synthetic low-toxicity lipid A derivative, DT-5461a, and indomethacin in various experimental tumor models of colon 26 carcinoma in mice
We investigated the antitumor effects of a synthetic lipid A derivative, DT-5461a, in combination with indomethacin in three… Expand
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1996
1996
Systemic administration of a synthetic lipid A derivative, DT-5461a, reduces tumor blood flow through endogenous TNF production in hepatic cancer model of VX2 carcinoma in rabbits.
Intravenous administration of DT-5461a, synthetic low-toxicity lipid A derivative, significantly inhibited the growth of VX2… Expand
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1995
1995
DT-5461a, an antitumor synthetic lipid a analog, causes selective blood flow reduction in tumor tissue.
We previously reported that a synthetic low-toxicity lipid A analog, DT-5461a, exhibited a significant antitumor effect was… Expand
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1995
1995
Production of tumor necrosis factor induced by synthetic low-toxicity lipid A analog, DT-5461a, is mediated by LPS receptor sites and tyrosine kinase-MAP kinase signaling pathway in murine…
The synthetic low-toxicity lipid A analog DT-5461a induces endogenous TNF production in mice. The activity of TNF so induced is… Expand
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1994
1994
Antitumor effect of DT-5461a, a synthetic low-toxicity lipid A analog, involves endogenous tumor necrosis factor induction subsequent to macrophage activation.
We previously showed that the synthetic lipid A derivative DT-5461a exhibited significant antitumor effects against various… Expand
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1994
1994
Antitumor synthetic lipid A analog DT-5461a upregulates cytokine expression in a murine macrophage cell line through LPS pathway.
We previously showed that DT-5461a, a lipid A analog, has antitumor activity and relatively low toxicity in animals. To clarify… Expand
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