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DSB 120
Known as:
DSB-120
National Institutes of Health
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Related topics
1 relation
Broader (1)
Benzodiazepinones
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Nuclear magnetic resonance solution structures of inter- and intrastrand adducts of DNA cross-linker SJG-136.
Suzanne R Hopton
,
A. Thompson
Biochemistry
2011
Corpus ID: 7213325
SJG-136 (1) is a sequence-selective DNA-interactive agent that is about to enter phase II clinical trials for the treatment of…
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2009
2009
Remarkable enhancement in the DNA-binding ability of C2-fluoro substituted pyrrolo[2,1-c][1,4]benzodiazepines and their anticancer potential.
A. Kamal
,
Rajender
,
+5 authors
G. N. Sastry
Bioorganic & medicinal chemistry
2009
Corpus ID: 38750033
Highly Cited
2003
Highly Cited
2003
Sequence-selective recognition of duplex DNA through covalent interstrand cross-linking: kinetic and molecular modeling studies with pyrrolobenzodiazepine dimers.
M. Smellie
,
D. S. Bose
,
A. Thompson
,
T. C. Jenkins
,
J. Hartley
,
D. Thurston
Biochemistry
2003
Corpus ID: 32136619
Members of a homologous series of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers with C8-O-(CH(2))(n)-O-C8' diether linkages (n…
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Highly Cited
2002
Highly Cited
2002
Design, synthesis, and evaluation of new noncross-linking pyrrolobenzodiazepine dimers with efficient DNA binding ability and potent antitumor activity.
A. Kamal
,
G. Ramesh
,
+6 authors
H. A. Nagarajaram
Journal of medicinal chemistry
2002
Corpus ID: 12778991
New sequence selective mixed imine-amide pyrrolobenzodiazepine (PBD) dimers have been developed that are comprised of DC-81 and…
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Highly Cited
2001
Highly Cited
2001
Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.
S. Gregson
,
P. Howard
,
+5 authors
D. Thurston
Journal of medicinal chemistry
2001
Corpus ID: 19872160
A novel sequence-selective pyrrolobenzodiazepine (PBD) dimer 5 (SJG-136) has been developed that comprises two C2-exo-methylene…
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1996
1996
Preclinical pharmacology and antitumour activity of the novel sequence-selective DNA minor-groove cross-linking agent DSB-120
M. Walton
,
P. Goddard
,
L. Kèlland
,
D. Thurston
,
K. Harrap
Cancer Chemotherapy and Pharmacology
1996
Corpus ID: 32706693
Abstract We examined the in vitro cytotoxicity, antitumour activity and preclinical pharmacokinetics of the novel sequence…
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Highly Cited
1994
Highly Cited
1994
Structure of a covalent DNA minor groove adduct with a pyrrolobenzodiazepine dimer: evidence for sequence-specific interstrand cross-linking.
T. C. Jenkins
,
L. Hurley
,
S. Neidle
,
D. Thurston
Journal of medicinal chemistry
1994
Corpus ID: 10846440
The structure of the interstrand cross-linked adduct formed between a C8-C8'-linked pyrrolobenzodiazepine (PBD) dimer (DSB-120; 1…
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1994
1994
Comparison of a DSB-120 DNA interstrand cross-linked adduct with the corresponding bis-tomaymycin adduct: an example of a successful template-directed approach to drug design based upon the…
J. Mountzouris
,
J. J. Wang
,
D. Thurston
,
L. Hurley
Journal of medicinal chemistry
1994
Corpus ID: 23706518
The interstrand cross-linked DSB-120-d(CICG*ATCICG)2 DNA adduct (*indicates covalently modified guanine) was examined by two…
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1994
1994
DNA damage by anticancer agents and its repair: mapping in cells at the subgene level with quantitative polymerase chain reaction.
K. Grimaldi
,
J. Bingham
,
R. Souhami
,
J. Hartley
Analytical biochemistry
1994
Corpus ID: 25715689
The quantitative polymerase chain reaction (QPCR)-based assay was used to measure DNA damage and repair to a small (523 bp…
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