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DSB 120

Known as: DSB-120 
National Institutes of Health

Papers overview

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2011
2011
SJG-136 (1) is a sequence-selective DNA-interactive agent that is about to enter phase II clinical trials for the treatment of… 
Highly Cited
2003
Highly Cited
2003
Members of a homologous series of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers with C8-O-(CH(2))(n)-O-C8' diether linkages (n… 
Highly Cited
2002
Highly Cited
2002
New sequence selective mixed imine-amide pyrrolobenzodiazepine (PBD) dimers have been developed that are comprised of DC-81 and… 
Highly Cited
2001
Highly Cited
2001
A novel sequence-selective pyrrolobenzodiazepine (PBD) dimer 5 (SJG-136) has been developed that comprises two C2-exo-methylene… 
1996
1996
Abstract We examined the in vitro cytotoxicity, antitumour activity and preclinical pharmacokinetics of the novel sequence… 
Highly Cited
1994
Highly Cited
1994
The structure of the interstrand cross-linked adduct formed between a C8-C8'-linked pyrrolobenzodiazepine (PBD) dimer (DSB-120; 1… 
1994
1994
The interstrand cross-linked DSB-120-d(CICG*ATCICG)2 DNA adduct (*indicates covalently modified guanine) was examined by two… 
1994
1994
The quantitative polymerase chain reaction (QPCR)-based assay was used to measure DNA damage and repair to a small (523 bp…