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DRGX gene

Known as: paired-like homeodomain trancription factor DRG11, DRG11, PRRXL1, MOUSE, HOMOLOG OF 
 
National Institutes of Health

Papers overview

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2014
2014
Ser¹¹⁹ phosphorylation modulates the activity and conformation of PRRXL1, a homeodomain transcription factor.
PRRXL1 [paired related homeobox-like 1; also known as DRG11 (dorsal root ganglia 11)] is a paired-like homeodomain transcription… Expand
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2011
2011
Postnatal expression of the homeobox gene Prrxl1 (Drg11) is increased in inflammatory but not neuropathic pain.
The paired-type homeodomain transcription factor Prrxl1 (also known as Drg11) is a key regulator of the differentiation and… Expand
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2010
2010
Prrxl1 is required for the generation of a subset of nociceptive glutamatergic superficial spinal dorsal horn neurons.
Perception of noxious events relies on activation of complex central neuronal circuits. The spinal cord dorsal horn plays a… Expand
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2009
2009
Expression of a Prrxl1 alternative splice variant during the development of the mouse nociceptive system.
BACKGROUND Gene expression can be differentially regulated by alternatively spliced transcription factors, providing a mechanism… Expand
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2008
2008
In DRG11 knock-out mice, trigeminal cell death is extensive and does not account for failed brainstem patterning.
A previous study (Ding et al., 2003) showed that the homeodomain transcription factor DRG11 is necessary for pattern formation in… Expand
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2006
2006
Involvement of DRG11 in the development of the primary afferent nociceptive system
During development, dorsal root ganglia (DRG) neurons differentiate in various subpopulations, nociceptive neurons belonging in… Expand
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Highly Cited
2004
Highly Cited
2004
DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties.
DRG11, a transcription factor expressed in embryonic dorsal root ganglion (DRG) and dorsal horn neurons, has a role in the… Expand
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2004
2004
Developmental regulation of homeobox gene expression in dorsal root ganglion neurons is not recapitulated during regeneration of the crushed sciatic nerve
The adult peripheral nervous system is able to regenerate after injury. Regeneration is associated with the expression of new… Expand
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Highly Cited
2001
Highly Cited
2001
The Paired Homeodomain Protein DRG11 Is Required for the Projection of Cutaneous Sensory Afferent Fibers to the Dorsal Spinal Cord
Cutaneous sensory neurons that detect noxious stimuli project to the dorsal horn of the spinal cord, while those innervating… Expand
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1995
1995
Identification by Differential RT-PCR of a Novel Paired Homeodomain Protein Specifically Expressed in Sensory Neurons and a Subset of Their CNS Targets
Sensory neurons are a major derivative of the neural crest for which there have been no definitive molecular markers in mammals… Expand
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