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DRF 4367
Known as:
DRF-4367
, DRF4367
National Institutes of Health
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Papers overview
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2006
2006
Glucuronidation of DRF-6574, hydroxy metabolite of DRF-4367 (a novel COX-2 inhibitor) by pooled human liver, intestinal microsomes and recombinant human UDP-glucuronosyltransferases (UGT): Role of…
Syed Muzeeb
,
Shaik Jafar Sadik Basha
,
Dhanya Shashikumar
,
R. Mullangi
,
N. Srinivas
European journal of drug metabolism and…
2006
Corpus ID: 29839171
SummaryDRF-4367 is a novel COX-2 inhibitor, which showed good efficacy in several animal models of inflammation. In a comparative…
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2006
2006
Bioavailability enhancement of poorly water soluble and weakly acidic new chemical entity with 2-hydroxy propyl-beta-cyclodextrin: selection of meglumine, a polyhydroxy base, as a novel ternary…
S. Basavaraj
,
V. Sihorkar
,
+5 authors
Sunil Kumar Singh
Pharmaceutical development and technology (Print)
2006
Corpus ID: 260620159
The purpose of the present study was to investigate the influence of a polyhydroxy base, N-acetyl glucamine (also know as…
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2005
2005
Validated HPLC analytical method with programmed wavelength UV detection for simultaneous determination of DRF-4367 and Phenol red in rat in situ intestinal perfusion study.
T. R. Shantha Kumar
,
Sonia Chawla
,
S. Nachaegari
,
S. Singh
,
N. Srinivas
Journal of Pharmaceutical and Biomedical Analysis
2005
Corpus ID: 9409706
2004
2004
2-hydroxymethyl-4-[5-(4-methoxyphenyl)-3-trifluoromethyl-1H-1-pyrazolyl]-1-benzenesulfonamide (DRF-4367): an orally active COX-2 inhibitor identified through pharmacophoric modulation.
S. Singh
,
Saibaba Vobbalareddy
,
+9 authors
K. R. Yeleswarapu
Organic and biomolecular chemistry
2004
Corpus ID: 8573334
Analogs of 1,5-diarylpyrazoles with a novel pharmacophore at N1 were designed, synthesized and evaluated for the in-vitro…
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2004
2004
HPLC method for determination of DRF-4367 in rat plasma: validation and its application to pharmacokinetics in Wistar rats.
R. Mullangi
,
R. Kallem
,
R. Bhamidipati
,
R. Mamidi
,
N. Srinivas
Biomedical chromotography
2004
Corpus ID: 38991307
A specific, accurate, precise and reproducible high-performance liquid chromatography (HPLC) method was developed for the…
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2003
2003
Oral bioavailability and pharmacokinetics of DRF-4367, a new cox-2 inhibitor in rats
M. Ramesh
,
R. Mamidi
,
+6 authors
N. Srinivas
European journal of drug metabolism and…
2003
Corpus ID: 10484586
SummaryThe pharmacokinetic characterization of DRF-4367 (a new diaryl pyrazole derivative), a potent selective COX-2 inhibitor…
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