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DOTAP:chol-Fus1 liposome complex

Known as: DOTAP:Cholesterol-Fus1 Liposome Complex, DOTAP:chol-Fus1, DOTAP:cholesterol-Fus1 
A formulation composed of DOTAP:cholesterol liposomal nanoparticles complexed with a plasmid expression cassette encoding human FUS1 protein, with… Expand
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
Gene therapy based on small interfering RNA (siRNA) has emerged as an exciting new therapeutic approach. However, insufficient… Expand
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2010
2010
In the treatment of peritoneal carcinomatosis, systemic chemotherapy is not quite effective due to the poor penetration of… Expand
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Highly Cited
2009
Highly Cited
2009
Complexes of cationic liposomes with DNA are promising tools to deliver genetic information into cells for gene therapy and… Expand
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Highly Cited
2007
Highly Cited
2007
Small interfering RNAs (siRNAs) of 19-25 bp mediate the cleavage of complementary mRNA, leading to post-transcriptional gene… Expand
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2007
2007
mRNA instead of DNA provides a new and attractive approach for gene therapy and genetic vaccination. Current technologies for… Expand
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Highly Cited
2004
Highly Cited
2004
To evaluate the role of lipid charge density in the serum stability of DOTAP-Chol/DNA complexes (lipoplexes), lipid-DNA… Expand
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Highly Cited
2004
Highly Cited
2004
Lung cancer is one of the leading causes of death in the world. The underlying cause for lung cancer has been attributed to… Expand
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Highly Cited
2002
Highly Cited
2002
Adenoviral vectors have been widely used for gene therapy, but they are limited both by the presence of a humoral immune response… Expand
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2002
2002
Lipid-mediated delivery of DNA into cells holds great promise both for gene therapy and basic research applications. This paper… Expand
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1999
1999
Lipoplexes, which are formed spontaneously between cationic liposomes and negatively charged nucleic acids, are commonly used for… Expand
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