DNA topoisomerase I activity

Known as: DNA topoisomerase type I activity, type I DNA topoisomerase activity, type I topoisomerase activity 
Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the… (More)

Topic mentions per year

Topic mentions per year

1983-2018
02419832018

Papers overview

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2010
2010
Identification of molecular mechanisms responsible for brain metastatic breast cancer (BMBC) is imperative to develop novel… (More)
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1998
1998
Eukaryotic DNA topoisomerase I catalyzes changes in the superhelical state of duplex DNA by transiently breaking single strands… (More)
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1997
1997
A camptothecin-resistant cell line that exhibits more than 600-fold resistance to camptothecin, designated CPT(R)-2000, was… (More)
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1996
1996
The tumor suppressor protein p53 plays a central role in the cellular response to genotoxic lesions and has been shown to be… (More)
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1992
1992
Purified human DNA topoisomerase I was assayed quantitatively by enzyme titrations with supercoiled pHC624 DNA in the presence of… (More)
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1992
1992
The DNA relaxation activity of Escherichia coli DNA topoisomerase I in vitro was greatly inhibited by cardiolipin. Inhibition… (More)
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1988
1988
We have isolated three different monoclonal antibodies specific for mammalian type-I DNA topoisomerase. The antibodies react with… (More)
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1988
1988
DNA topoisomerase I has been purified to electrophoretic homogeneity from ovaries of the frog Xenopus laevis. Sodium dodecyl… (More)
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1984
1984
Mutants of the yeast, Saccharomyces cerevisiae, deficient in DNA topoisomerase I activity have been identified. One mutant has… (More)
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1984
1984
Chromatin-associated DNA topoisomerase I activity was measured in human diploid fibroblasts during in vitro aging. No difference… (More)
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