DNA deamination

The removal of an amino group from a nucleotide base in DNA. An example is the deamination of cytosine to produce uracil. [GOC:ai]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2018
051019952018

Papers overview

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Highly Cited
2006
Highly Cited
2006
The most common transposable genetic element in humans, long interspersed element 1 (L1), constitutes about 20% of the genome… (More)
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Highly Cited
2004
Highly Cited
2004
To investigate the extent to which in vivo mutation spectra might reflect the intrinsic specificities of active mutators, genetic… (More)
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Highly Cited
2003
Highly Cited
2003
CEM15/APOBEC3G is a cellular protein required for resistance to infection by virion infectivity factor (Vif)-deficient human… (More)
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Highly Cited
2003
Highly Cited
2003
Activation-induced cytidine deaminase (AID), which is specific to B lymphocytes, is required for class switch recombination (CSR… (More)
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Highly Cited
2003
Highly Cited
2003
The human protein apolipoprotein B mRNA-editing enzyme–catalytic polypeptide-like-3G (APOBEC3G), also known as CEM-15, mediates a… (More)
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Highly Cited
2003
Highly Cited
2003
Replication of human immunodeficiency virus type 1 (HIV-1) in most primary cells and some immortalized T-cell lines depends on… (More)
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Highly Cited
2002
Highly Cited
2002
After gene rearrangement, immunoglobulin variable genes are diversified by somatic hypermutation or gene conversion, whereas the… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND We have previously proposed that deamination of cytosine to uracil at sites within the immunoglobulin loci by… (More)
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Highly Cited
2002
Highly Cited
2002
A functional immune system depends on the production of a wide range of immunoglobulin molecules. Immunoglobulin variable region… (More)
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1995
1995
Inflammatory cells such as phagocytes, neutrophils, and macrophages have been implicated in the pathogenesis of several forms of… (More)
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