DNA (cytosine-5-)-methyltransferase 1

Known as: DNA Methyltransferase HsaI, DNA (Cytosine-5)-Methyltransferase 1, DNMT1 
DNA (cytosine-5)-methyltransferase 1 protein (1613 aa, ~183 kDa) is encoded by the human DNMT1 gene. This soluble, nuclear protein is involved in… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2017
0102019972017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Reactivation of silenced tumor suppressor genes by 5-azacytidine (Vidaza) and its congener 5-aza-2'-deoxycytidine (decitabine… (More)
  • figure 2
  • figure 3
  • figure 4
  • figure 5
  • figure 6
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Alterations in cytosine methylation patterns are usually observed in human tumors. The consequences of altered cytosine… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Chromatin methylation is necessary for stable repression of gene expression during mammalian development. During cell division… (More)
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Previous studies have shown that DNA methyltransferase (Dnmt) 1 is required for maintenance of bulk DNA methylation and is… (More)
Is this relevant?
Highly Cited
2005
Highly Cited
2005
5-Azacytidine- and 5-aza-deoxycytidine (5-aza-CdR)-mediated reactivation of tumor suppressor genes silenced by promoter… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2005
Highly Cited
2005
We provided evidence that competitive inhibition of poly(ADP-ribose) polymerases in mammalian cells treated with 3-aminobenzamide… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Transcriptional silencing by CpG island methylation is a prevalent mechanism of tumor-suppressor gene suppression in cancers… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2000
Highly Cited
2000
DNA methylation can contribute to transcriptional silencing through several transcriptionally repressive complexes, which include… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2000
Highly Cited
2000
DNA methylation is essential for mammalian development, X-chromosome inactivation, and imprinting yet aberrant methylation… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
1997
Highly Cited
1997
DNA-(cytosine-5) methyltransferase (MCMT) methylates newly replicated mammalian DNA, but the factors regulating this activity are… (More)
Is this relevant?